Results 51 to 60 of about 308,507 (245)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Something, nothing : space, substance, and sexual identity in Shakespeare [PDF]

open access: yes, 1981
This paper argues that early, "preoedipal" anxieties about dependency, autonomy, the boundaries of the self, the dangerous interpenetration of inner and outer worlds--the outer world contaminating the inner self, the self afraid of losing the precious
Splitter, Randolph
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Hofstede’s Cultural Dimensions and Tourist Behaviors: A Review and Conceptual Framework [PDF]

open access: yes
This paper develops a conceptual framework for analyzing tourist behaviors and identifies three categories of behaviors based on the applications of Hofstede’s cultural dimensions and the processes underlying these influences.
Manrai, Ajay K., Manrai, Lalita A.
core  

Conflict Resolution: Cultural Understanding Imperative [PDF]

open access: yes, 2012
Business transactions and other potential incidences of conflict resolution must be met by participants who have transcended the isolating and often arrogant traits of individualism and must expand to embrace the collective — to realize the importance of
Tindal, Livingston S
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Living in the garden of Eden: Mineral resources foster individualism [PDF]

open access: yes
Using mineral resources discoveries in the United States since 1800, we argue that mineral mining fosters individualism. Measuring individualism and the demand for redistribution by questions of the General Social Survey (GSS), we show that: (i ...
Marc Sangnier, Mathieu Couttenier
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

A century of methodological individualism part 1: Schumpeter and Menger [PDF]

open access: yes, 2010
2009 marks the centenary of methodological individualism (MI). The phrase was first used in English in a 1909 QJE paper by Joseph Schumpeter. Yet after 100 years there is considerable confusion as to what the phrase means.
Denis, A.
core  

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