Results 81 to 90 of about 313,352 (311)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

The MNC as an Agent of Change for Host-Country Institutions: FDI and Corruption [PDF]

open access: yes, 2006
Most empirical research examines how the institutional environment of corruption shapes the behavior of MNCs. In this study, we would like to highlight the other side of the picture: how the presence of MNC may shape the institutional environment of ...
Kwok, Chuck, Tadesse, Solomon
core   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

HOW DO JAPANESE PERCEIVE INDIVIDUALISM? EXAMINATION OF THE MEANING OF INDIVIDUALISM IN JAPAN [PDF]

open access: yes, 2014
It has been suggested that individualistic systems have been recently employed in Japan, and Japanese people have become more individualistic. However, previous research suggested that such cultural changes have negative associations with interpersonal ...
Kusumi, Takashi   +2 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Terrorismo individual = Individual terrorism

open access: yesEUNOMÍA. Revista en Cultura de la Legalidad, 2018
Resumen: Los atentados perpetrados por actores solitarios en los últimos años han despertado el interés del legislador por la figura del terrorismo individual. No obstante, aunque este se regula en las últimas reformas penales, no se ha dispuesto una definición del mismo en términos positivos, sino que ésta únicamente se dispone en términos negativos ...
openaire   +2 more sources

Holism, individualism, personalism: from Platonic dualism to the dispute over a source and status of human individuality (N. Elias, I. Berlin, R. Rorty) [PDF]

open access: yesAnaliza i Egzystencja, 2015
Individualism as a way of feeling and comprehension of reality has been a basic element of Western civilization for a long time. In 20th century individualism was criticized by personalism and similar currents.
Zbigniew Ambrożewicz
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

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