Results 81 to 90 of about 313,352 (311)
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
The MNC as an Agent of Change for Host-Country Institutions: FDI and Corruption [PDF]
Most empirical research examines how the institutional environment of corruption shapes the behavior of MNCs. In this study, we would like to highlight the other side of the picture: how the presence of MNC may shape the institutional environment of ...
Kwok, Chuck, Tadesse, Solomon
core +1 more source
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
HOW DO JAPANESE PERCEIVE INDIVIDUALISM? EXAMINATION OF THE MEANING OF INDIVIDUALISM IN JAPAN [PDF]
It has been suggested that individualistic systems have been recently employed in Japan, and Japanese people have become more individualistic. However, previous research suggested that such cultural changes have negative associations with interpersonal ...
Kusumi, Takashi +2 more
core +1 more source
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Terrorismo individual = Individual terrorism
Resumen: Los atentados perpetrados por actores solitarios en los últimos años han despertado el interés del legislador por la figura del terrorismo individual. No obstante, aunque este se regula en las últimas reformas penales, no se ha dispuesto una definición del mismo en términos positivos, sino que ésta únicamente se dispone en términos negativos ...
openaire +2 more sources
Holism, individualism, personalism: from Platonic dualism to the dispute over a source and status of human individuality (N. Elias, I. Berlin, R. Rorty) [PDF]
Individualism as a way of feeling and comprehension of reality has been a basic element of Western civilization for a long time. In 20th century individualism was criticized by personalism and similar currents.
Zbigniew Ambrożewicz
doaj
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source

