Results 111 to 120 of about 345,912 (334)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Individuality and Source of Violence [PDF]
This is a (very) introductory paper to a forthcoming existentalist account of moral absolutism and violence. It was written for and presented at ICPR Seminar 2018.
Rajan, Sahana
core
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Творча індивідуальність як критерій педагогічної майстерності викладача вищої школи [PDF]
, 2017 У статті обгрунтовано залежність успішності педагогічної діяльності викладача вищої школи та його здатності управляти якістю університетської освіти від рівня розвитку його педагогічної майстерності та творчої індивідуальності.
Отич, О. (O. Otych)
core
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Autonomy in Stratified Structures
Studia HumanaThis article proposes a minimalist concept of autonomy that is consistent with determinism, but negates fatalism. Drawing on Nicolai Hartmann’s stratified ontology, it argues that autonomy is achieved not by suspending physical laws, but by introducing ...
Dzierwa Rafał
doaj +1 more source
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
Meadian reflections on the existential ambivalence of human selfhood [PDF]
, 2010 This paper examines the existential ambivalence of human selfhood by drawing upon George Herbert Mead’s distinction between the ‘I’ and the ‘me’. In order to make a case for the centrality of this conceptual distinction, the paper offers a comprehensive
Susen, Simon
core
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source