Results 81 to 90 of about 355,662 (382)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

open access: yesFEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali   +3 more
wiley   +1 more source

Natural Selection beyond Life? A Workshop Report

open access: yesLife, 2021
Natural selection is commonly seen not just as an explanation for adaptive evolution, but as the inevitable consequence of “heritable variation in fitness among individuals”. Although it remains embedded in biological concepts, such a formalisation makes
Sylvain Charlat   +15 more
doaj   +1 more source

Symbiosis As The Way Of Eukaryotic Life: The Dependent Co-Origination Of The Body [PDF]

open access: yes, 2014
Molecular analyses of symbiotic relationships are challenging our biological definitions of individuality and supplanting them with a new notion of normal part whole relationships. This new notion is that of a \u27holobiont\u27, a consortium of organisms
Gilbert, Scott F.
core   +2 more sources

On individual risk [PDF]

open access: yesSynthese, 2015
We survey a variety of possible explications of the term "Individual Risk." These in turn are based on a variety of interpretations of "Probability," including Classical, Enumerative, Frequency, Formal, Metaphysical, Personal, Propensity, Chance and Logical conceptions of Probability, which we review and compare.
openaire   +3 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

open access: yesFEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac   +3 more
wiley   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

open access: yesFEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi   +3 more
wiley   +1 more source

Breeding bird density does not drive vocal individuality

open access: yesCurrent Zoology, 2012
Many species produce individually specific vocalizations and sociality is a hypothesized driver of such individuality. Previous studies of how social variation influenced individuality focused on colonial or non-colonial avian species, and how social ...
Daniel T. BLUMSTEIN, Douglas R. MCCLAIN, Carrie DE JESUS, Gustavo ALARCÓN-NIETO
doaj  

The Relation Between Soul And Body and its Eschatological Consequences in Jacob Boehme’s Philosophy With Regard to Mulla Sadra's Position Reza Akbarian [PDF]

open access: yesحکمت و فلسفه, 2010
Even though Mulla Sadra and Jacob Boehme come from two different traditions and despite the absence of philosophical formation of the latter, a similar visionary experience led them to lay the basis of a conception of man which has many shared aspects ...
reza akbarian, amili noigeliz
doaj   +1 more source

Children, Humanoid Robots and Caregivers [PDF]

open access: yes, 2004
This paper presents developmental learning on a humanoid robot from human-robot interactions. We consider in particular teaching humanoids as children during the child's Separation and Individuation developmental phase (Mahler, 1979).
Arsenio, Artur
core   +1 more source

A metaphysical approach to holobiont individuality: Holobionts as emergent individuals

open access: yesQuaderns de Filosofia, 2019
Holobionts are symbiotic assemblages composed by a host plus its microbiome. The status of holobionts as individuals has recently been a subject of continuous controversy, which has given rise to two main positions: on the one hand, holobiont advocates ...
J. Suárez, Vanessa Triviño
semanticscholar   +1 more source

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