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Indoxyl Sulfate Induces Nephrovascular Senescence
Journal of Renal Nutrition, 2012Indoxyl sulfate is markedly accumulated in the serum of chronic kidney disease (CKD) patients. The oral sorbent AST-120 reduces serum levels of indoxyl sulfate in CKD patients by adsorbing indole, a precursor of indoxyl sulfate, in the intestine. Indoxyl sulfate is taken up by proximal tubular cells through organic anion transporters (OAT1, OAT3), and ...
Toshimitsu, Niwa, Hidehisa, Shimizu
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Growth-Promoting Activity of Potassium Indoxyl Sulfate and Indoxyl Acetate
Botanical Gazette, 19541. In this paper exploratory experiments have been described in which some oxidized indole derivatives have stimulated slightly the growth of corn coleoptile sections. 2. When potassium indoxyl sulfate and indoxyl acetate were supplied, light appeared to modify greatly the growth response. 3. Whether considered as degradation products in the metabolism
Richard C. French, Harry Beevers
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Indoxyl Sulfate and Arteriosclerosis
2020The uremic toxin indoxyl sulfate, metabolized from dietary tryptophan, accumulates in the serum of patients with decreased renal function. A higher level of serum indoxyl sulfate is reported to be an independent risk factor for cardiovascular events and death in patients with chronic kidney disease.
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Indoxyl Sulfate Is a Nephro-Vascular Toxin
Journal of Renal Nutrition, 2010Indoxyl sulfate is markedly accumulated in the serum of patients with chronic kidney disease (CKD). The oral sorbent AST-120 reduces the serum levels of indoxyl sulfate in CKD patients by adsorbing indole, a precursor of indoxyl sulfate, in the intestine, and thereby stimulating its excretion in feces. AST-120 is used for the treatment of patients with
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Engineered binding sites for indoxyl sulfate and p-cresol sulfate
2023The removal of uremic toxins is of great importance in preventing the progression of chronic kidney disease. The investigation of the interaction of uremic toxins with serum and dialysis materials will contribute to the advancement of techniques in uremic toxins removal.
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Performance evaluation of an Indoxyl Sulfate Assay Kit “NIPRO”
Clinical Chemistry and Laboratory Medicine (CCLM), 2019Abstract Background The relationship between renal disease and cardiovascular disease (CVD) is currently known as cardiorenal syndrome. Indoxyl sulfate (IS) is one of the uremic toxins that accelerates the progression of cardiorenal syndrome.
Yuki, Fushimi +5 more
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Indoxyl Sulfate and Atherosclerotic Risk Factors in Hemodialysis Patients
American Journal of Nephrology, 2007<i>Background:</i> Indoxyl sulfate is a uremic toxin that accelerates the progression of chronic kidney disease (CKD). Serum levels of indoxyl sulfate are increased in dialysis patients. It was reported that indoxyl sulfate plays a role in endothelial dysfunction in uremic patients, and stimulates proliferation of rat vascular smooth muscle
Kentaro, Taki +2 more
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Indoxyl sulfate, a uremic toxin, is biotransformed from indoxyl-β-d-glucoside (indican) in rats
Toxicon, 2008Indican (Indoxyl-beta-D-glucoside) is present in many Chinese herbs such as Isatis indigotica, Clerodendrum crytophyllum, Glehnia littoralis, Polygonum tinctorium and P. perfoliatum. This study aims to investigate whether indoxyl sulfate, a uremic toxin, would be biotransformed from indican in rats.
Yu-Chi, Hou +4 more
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Effect of uremic toxin-indoxyl sulfate on the skeletal system
Clinica Chimica Acta, 2018Chronic kidney disease-mineral bone disorders (CKD-MBD) exhibit abnormalities in the circulating mineral levels, vitamin D metabolism, and parathyroid function that contribute to the formation of a bone lesion. The uremic toxin, indoxyl sulfate (IS), accumulates in the blood in cases of renal failure and leads to bone loss. The bone and renal responses
Wen-Chih, Liu +8 more
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Association Between Indoxyl Sulfate and Skeletal Resistance in Hemodialysis Patients
Therapeutic Apheresis and Dialysis, 2010AbstractSkeletal resistance to parathyroid hormone (PTH) in uremia is known, although the mechanism of resistance is not fully elucidated. To clarify the roles of indoxyl sulfate, which is a uremic toxin, in skeletal resistance, we examined the relationship between indoxyl sulfate and biochemical markers of bone turnover in hemodialysis patients.
Shunsuke, Goto +4 more
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