Results 131 to 140 of about 8,336,024 (249)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Detecting induced subgraphs [PDF]

An s-graph is a graph with two kinds of edges : subdivisible edges and real edges. A realisation of an s-graphB is any graph obtained by subdividing subdivisible edges of B into paths of arbitrary length (at least one).
Nicolas Trotignon, Benjamin Lévêque, David Y. Lin, Frédéric Maffray   +3 more
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Renin-Angiotensin Signaling and Vascular Function: Insights into Health and Disease. [PDF]

Acta Physiol (Oxf)
Bertoldi G, Sonkusare SK.
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Predator-induced morphological traits determine escape performance in a larval amphibian species. [PDF]

R Soc Open Sci
Matsuura N, Malinda RR, Fukuda S, Kawashima H, Kishida O.   +4 more
europepmc   +1 more source

FEATURED ARTICLE

, 2014
The objective of this study was to characterize levodopa (L-dopa)–induced dyskinesias in patients with tyrosine hydroxylase deficiency. Clinical observation was carried out on 6 patients who were diagnosed with tyrosine hydroxylase deficiency and were ...
Levodopa-induced Dyskinesias, Tyrosine Hydroxylase Deficiency   +1 more
core  

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

IGFBP2 attenuates high glucose-induced endothelial dysfunction through PI3K/Akt/eNOS pathway activation. [PDF]

Biosci Rep
Song X, Zhong W, Chen C, Zheng H, Li Z.
europepmc   +1 more source

Handbook on the reporting of induced termination of pregnancy : reprinted from 1988, includes Revised Instruction and Reporting Form, 1997 [PDF]

"This handbook is prepared by the National Center for Health Statistics, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, and contains instructions for persons with responsibilities for completing and filing ...

core