Results 51 to 60 of about 129,628 (329)

Single Fusion Pore Analysis via Single Cell Amperometry Uncovers Impaired Pore Expansion That Restricts Insulin Exocytosis in Human Type 2 Diabetes

Angewandte Chemie, EarlyView.
The final step in insulin exocytosis from pancreatic beta cells is the formation of the fusion pore. We combined single‐cell amperometry with microsensors and fluorescence microscopy to monitor insulin exocytosis from different perspectives. Our results reveal a link between impaired fusion pore function and diminished insulin secretion, highlighting ...
Amir Hatami, Nikhil R. Gandasi, Haiqiang Dou, Lakshmi Kothegala, Lena Eliasson, Andrew Ewing, Patrik Rorsman   +6 more
wiley   +2 more sources

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

Advanced Science, EarlyView.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li, Rui Wang, Wenting Luo, Hui Gu, Tianchu Huang, Qiushi Wang, Zhengwei Yuan   +6 more
wiley   +1 more source

Willingness to perform induced abortion and associated factors among graduating midwifery, medical, nursing, and public health officer students of University of Gondar, Northwest Ethiopia: institution based cross sectional study

BMC Pregnancy and Childbirth, 2020
Background In developing countries, abortion is often unsafe and a significant cause of maternal morbidity and mortality accounting for about 8% (4.7–13.2%) of maternal mortality worldwide.
Mihretu Molla Enyew
doaj   +1 more source

Repeat-induced abortion and associated factors among reproductive-age women seeking abortion services in South Ethiopia

Women's Health, 2022
Introduction: Despite the advances in modern health care, maternal morbidity and mortality remain major problems in Ethiopia. Repeat-induced abortion is an indispensable contributor to this problem.
Girma Geta, Kenbon Seyoum, Degefa Gomora, Chala Kene, Berhan Tsegaye, Zelalem Tenaw   +5 more
doaj   +1 more source

Denial of abortion in legal settings. [PDF]

, 2014
BackgroundFactors such as poverty, stigma, lack of knowledge about the legal status of abortion, and geographical distance from a provider may prevent women from accessing safe abortion services, even where abortion is legal.
DePiñeres, Teresa, Foster, Diana Greene, Gerdts, Caitlin, Hajri, Selma, Harries, Jane, Hossain, Altaf, Puri, Mahesh, Vohra, Divya   +7 more
core   +1 more source

BLOC1S1 Attenuates B. Melitensis 16M LPS‐Triggered Autophagy by Spatial Confinement of TDP‐43

Advanced Science, EarlyView.
This study explores how B. melitensis 16M LPS and BLOC1S1 regulate autophagy in goat spermatogonial stem cells. The 16M LPS is activating AMPK‐dependent autophagy, increasing LC3B‐II/I ratios and lysosomal genes, while Escherichia coli LPS shows no effect.
Shicheng Wan, Miao Han, Mengfei Zhang, Wenbo Chen, Fangde Xie, Xuan Luo, Wenping Wu, Congliang Wang, Donghui Yang, Bin Han, Haijing Zhu, Haisheng Yu, Na Li, Jinlian Hua   +13 more
wiley   +1 more source

Developing a comprehensive abortion prevention program for couples based on I-change model: study protocol for a mixed method research

Reproductive Health
Background In countries where abortion laws are stringent, induced abortions are prevalent. The limited availability of abortion services within these regions amplifies the likelihood of maternal complications and mortality. Induced abortions represent a
Zari Dolatabadi, Maryam Moridi, Farnaz Farnam, Maryam Damghanian   +3 more
doaj   +1 more source

Attitudes of Married Women Towards Induced Abortion in Manisa

İstanbul Medical Journal, 2019
Introduction:This study was aimed at revealing attitudes of married women towards induced abortion.Methods:This study was descriptive and the study population included 64.382 married women aged 15-49 years in the city of Manisa.
Dilek Özmen, Aynur Çakmakçı Çetinkaya, Seval Cambaz Ulaş, Nursen Bolsoy   +3 more
doaj   +1 more source

Nociceptive Nerve‐Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140b+ CD146+ Fibroblast Differentiation

Advanced Science, EarlyView.
This study investigates adenomyosis fibrosis in relation to nociceptive nerves. Nociceptive nerve‐secreted CGRP promotes RAMP1hi CD140b+ CD146+ fibroblast differentiation into myofibroblasts through ERK activation, causing severe fibrosis. Rimegepant‐induced CGRP/RAMP1 signaling blockade alleviates fibrosis and restores fertility in a mouse model. This
Zi Ye, Anning Zhao, Xia Li, Yanqing Hao, Dong Huang, Jianmin Chen, Tiantian Li, Yangyang Dai, Wenchao Sun, Lie Ma, Songying Zhang, Liaobing Xin   +11 more
wiley   +1 more source

BHLHE40 Cooperates with GATA2/3 to Control Human Syncytiotrophoblast Lineage Differentiation

Advanced Science, EarlyView.
BHLHE40 interacts directly with GATA2 and GATA3 and co‐occupies genomic loci critical for STB differentiation and function. BHLHE40 also affects GATA2/3 binding at enhancer and promoter regions. Moreover, BHLHE40 is potentially involved in genome‐wide remodeling of H3K4me3 and H3K27ac chromatin landscapes through GATA2/3 recruitment, activating ...
Lijin Peng, Weijie Zhao, Chunfang Xu, Yue Li, Jiani Guo, Taotao Zhou, Philip Chiu, Huimei Wu, Qingyu Wu, Yanxing Wei, Shaorong Gao, Meirong Du   +11 more
wiley   +1 more source