Results 41 to 50 of about 416,586 (294)

Elicitation of Induced Resistance against Pectobacterium carotovorum and Pseudomonas syringae by Specific Individual Compounds Derived from Native Korean Plant Species

Molecules, 2013
Plants have developed general and specific defense mechanisms for protection against various enemies. Among the general defenses, induced resistance has distinct characteristics, such as broad-spectrum resistance and long-lasting effectiveness.
Choong-Min Ryu, Young Sup Kim, Ji Young Lee, Jung Sup Choi, Shi Yong Ryu, Geun Cheol Song   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Boosting potato defence against late blight [PDF]

, 2013
For more than one century efforts has been made to obtain potato (Solanum tuberosum) cultivars resistant to late blight. However, introduced resistance has repeatedly been overcome by Phytophthora infestans (Mont) de Bary.
Bengtsson, Therése
core  

Mycorrhiza-induced resistance: more than the sum of its parts? [PDF]

, 2013
Plants can develop an enhanced defensive capacity in response to infection by arbuscular mycorrhizal fungi (AMF). This ‘mycorrhiza-induced resistance’ (MIR) provides systemic protection against a wide range of attackers and shares characteristics with ...
Cameron, D. D., Cameron, D.D.; id_orcid, Neal, A. L., Van Wees, S. C. M., Cameron, D.D., van Wees, S.C.M., Sub Plant-Microbe Interactions, Ton, J., Neal, A.L., Dep Biologie, Neal, A., Plant Microbe Interactions   +11 more
core   +1 more source

MBOAT7-driven lysophosphatidylinositol acylation in adipocytes contributes to systemic glucose homeostasis

Journal of Lipid Research, 2023
We previously demonstrated that antisense oligonucleotide-mediated knockdown of Mboat7, the gene encoding membrane bound O-acyltransferase 7, in the liver and adipose tissue of mice promoted high fat diet-induced hepatic steatosis, hyperinsulinemia, and ...
William J. Massey, Venkateshwari Varadharajan, Rakhee Banerjee, Amanda L. Brown, Anthony J. Horak, Rachel C. Hohe, Bryan M. Jung, Yunguang Qiu, E. Ricky Chan, Calvin Pan, Renliang Zhang, Daniela S. Allende, Belinda Willard, Feixiong Cheng, Aldons J. Lusis, J. Mark Brown   +15 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Salicylic Acid and Jasmonic Acid Are Essential for Systemic Resistance Against Tobacco mosaic virus in Nicotiana benthamiana

Molecular Plant-Microbe Interactions, 2014
Systemic resistance is induced by pathogens and confers protection against a broad range of pathogens. Recent studies have indicated that salicylic acid (SA) derivative methyl salicylate (MeSA) serves as a long-distance phloem-mobile systemic resistance ...
Feng Zhu, De-Hui Xi, Shu Yuan, Fei Xu, Da-Wei Zhang, Hong-Hui Lin   +5 more
doaj   +1 more source