Results 91 to 100 of about 45,041 (307)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Simulating Inductance using Operational Amplifiers [PDF]
, 1974 application/pdfIt have been reported the method to realized the grounded inductance and ungrounded inductance using operational amplifiers，in a recent papers. However，it has been remained the problems for adding elements and frequency band.
沖根, 光夫 +2 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Journal of Electrical Bioimpedance, 2010 Bioimpedance measurements are of great use and can provide considerable insight into biological processes. However, there are a number of possible sources of measurement error that must be considered. The most dominant source of error is found in bipolar
Callaghan Martina F. +3 more
doaj +1 more source
Experimental Characterization of Frequency-Dependent Series Resistance and Inductance for Ground Shielded On-Chip Interconnects [PDF]
, 2013 This paper presents an exhaustive analysis of the frequency-dependent series resistance and inductance associated with the distributed model of on-chip interconnects including a ground shield to reduce substrate losses.
Reydezel Torres Torres +3 more
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Quotient inductive-inductive definitions [PDF]
, 2017 In this thesis we present a theory of quotient inductive-inductive definitions, which are inductive-inductive definitions extended with constructors for equations. The resulting theory is an improvement over previous treatments of inductive-inductive and indexed inductive definitions in that it unifies and generalises these into a single framework. The
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source