Results 201 to 210 of about 158,217 (287)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Geometry optimization of broadband, planar, spiral inductors via continuous trace width modulation. [PDF]

open access: yesSci Rep
Cañada J   +4 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Programmable soliton dynamics in all-Josephson-junction logic cells and networks. [PDF]

open access: yesBeilstein J Nanotechnol
Ruzhickiy VI   +7 more
europepmc   +1 more source

CLINICAL AND PREVENTIVE EFFICACY OF INTERFERON INDUCTOR IN VIRAL RESPIRATORY TRACT INFECTIONS IN CHILDREN YOUNGER PRESCHOOL AGE

open access: diamond, 2012
Ф С Харламова   +4 more
openalex   +2 more sources

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