Results 41 to 50 of about 87,780 (264)

Microwave Kinetic Inductance Detectors [PDF]

, 2005
Low temperature detectors have been a subject of intense interest to the scientific community over the last decade. These detectors work at very low temperatures, often well below 1 Kelvin, to minimize the noise in the measurement of photons.
Mazin, Benjamin A.
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

CCII-Based High-Valued Inductance Simulators with minumum Number of Active Elements

, 2007
This paper presents novel CCII-based circuit solutions for the implementation of grounded and floating inductance simulators for integrable low frequency applications.
N. GUERRINI, N. C. Guerrini, G. Scotti, TRIFILETTI, Alessandro, R. ROMANATO, G. FERRI, A. Trifiletti, SCOTTI, Giuseppe, FERRI, GIUSEPPE   +8 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

A frequency-accurate discrete proportional–resonant control strategy for grid simulators

Frontiers in Energy Research
Accurate sinusoidal-voltage reproduction is essential for converter-based grid simulators used to evaluate renewable-energy and energy-storage equipment under normal and abnormal grid conditions.
Zhichao Xue, Jinru Hu, Hongfeng Li, Hongfeng Li, Xudong Lu, Shishan Dong, Shishan Dong, Xiuyuan Wu, Fei Lin   +8 more
doaj   +1 more source

New active realizations of floating lossless inductance and R-L impedance simulators

, 2004
A new realization of floating inductance and two R-L impedance simulators are presented, respectively employing three and two first generation current conveyors (CCI)s as active elements.
Metin, Bilgin, Minaei, Shahram, Çiçekoğlu, Mehmet Oğuzhan, Yıldız, Merih, M. Yildiz, S. Minaei, O. Cicekoglu, B. Metin   +7 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Influence of Inertial Stimulus on Visuo-Vestibular Cues Conflict for Lateral Dynamics at Driving Simulators [PDF]

, 2013
Version éditeur de cet article : Aykent B, Merienne F, Paillot D, Kemeny A (2013) Influence of Inertial Stimulus on Visuo-Vestibular Cues Conflict for Lateral Dynamics at Driving Simulators. J Ergonomics 3: 113.
KEMENY, Andras, MERIENNE, Frédéric, Frédéric, Merienne, AYKENT, Baris, PAILLOT, Damien   +4 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source