Results 111 to 120 of about 3,833,099 (322)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Experimental and finite element studies of a 250 kW brushless doubly fed induction generator

open access: yesThe Journal of Engineering, 2019
This study studies, using experimentally verified finite element (FE) analysis, various performance measures of the brushless doubly fed induction generator (BDFIG) when magnetic wedges are used for closing stator open slots.
Salman Abdi, Ehsan Abdi, Richard McMahon
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Analytical Model of Eccentric Induction Machines Using the Conformal Winding Tensor Approach. [PDF]

open access: yesSensors (Basel), 2022
Terron-Santiago C   +5 more
europepmc   +1 more source

Complexity Hierarchies Beyond Elementary

open access: yes, 2016
We introduce a hierarchy of fast-growing complexity classes and show its suitability for completeness statements of many non elementary problems. This hierarchy allows the classification of many decision problems with a non-elementary complexity, which ...
Schmitz, Sylvain
core   +3 more sources

Machine learning and grammar induction [PDF]

open access: yesMachine Learning, 1987
Despite its complexity, the task of natural language processing can be divided into a number of well-defined subtasks, and one of these centers on syntax. This aspect of language has been studied in detail by linguists, and developmental studies have provided a variety of empirical generalizations about the stages that children traverse in their ...
openaire   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

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