Results 291 to 300 of about 466,696 (361)
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Soft starting of two-phase induction motor using power electronics
, 2005 Almir Laranjeira Neri
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Induction motor variable inductance parameter identification
2017 International Conference on Smart Systems and Technologies (SST), 2017Paper derives a procedure of identifying induction machine variable inductance values. Parameter identification is done from measurements during no-load direct start acceleration. Genetic algorithm is used for parameter identification. It is used to minimise least squares difference between calculated and measured data by selecting parameters of ...
Halak, Filip +2 more
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Induction motor drive parameters identification
IEEE Transactions on Power Electronics, 1998The paper deals with real-time identification of the rotor parameters of the induction motor drive. The model reference adaptative control technique has been used for synthesising two identifiers. An appropriate choice of the reference model allows a Lyapunov function to be built by means of which the updating law of the rotor time constant can be ...
Attaianese C +4 more
openaire +7 more sources
Journal of the A.I.E.E., 1930
Magnetic noise in induction motors is caused by the vibration of magnetic parts produced by the varying forces associated with the changing flux density in the adjacent air parts of the magnetic circuit. Torsional vibration of the motor is caused by unbalanced windings or applied voltages.
openaire +1 more source
Magnetic noise in induction motors is caused by the vibration of magnetic parts produced by the varying forces associated with the changing flux density in the adjacent air parts of the magnetic circuit. Torsional vibration of the motor is caused by unbalanced windings or applied voltages.
openaire +1 more source