Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Review of Fault Diagnosis Methods for Induction Machines in Railway Traction Applications
EnergiesInduction motors make up approximately 80% of the electric motors in the railway sector due to their robustness, high efficiency, and low maintenance cost.
Razan Issa +6 more
doaj +1 more source
Time-Domain, Steady-State Torque Calculation of Voltage-Source Pulse-Width-Modulated Inverter Fed Induction Motors [PDF]
Evaluation of torque pulsation associated with the harmonics of pulse width modulated (PWM) inverter-fed drives is important, particularly at low speed.
Hsu, J.S.
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Impact of increased distributed generation on fault levels and the network equipment [PDF]
, 2014 Attention towards the development of Distributed Generation (DG) is globally high. UK's concentration is to use sustainable and renewable sources to generate electricity thereby protecting the environment from getting polluted. In this paper, Distributed
Bhavanam, YR, Shahrazad, M
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Detection of Broken Rotor Bars in Cage Induction Motors Using Machine Learning Methods. [PDF]
Sensors (Basel), 2023 Chisedzi LP, Muteba M.
europepmc +1 more source
Calculation of Electromagnetic Fields in Electrical Machines using Finite Elements Method [PDF]
, 2011 Finite Elements Method is a contemporary numerical method for determination of distribution of electromagnetic fields inside different objects. In this paper three different induction motors will be analyzed : Solid Salient Poles Synchronous Motor ...
Sarac, Vasilija
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