Results 101 to 110 of about 144,167 (351)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Pulse diffusion welding of female joints

Frontier Materials & Technologies
Special feature of operation of electrovacuum tubes, in particular the cathode assembly, is constant heating due to bombardment of its surface with electrons. Stable characteristics and durability of the cathode assembly depend on high-quality connection
Evgeny L. Strizhakov, Stanislav V. Nescoromniy, Yury G. Lyudmirsky, Nikolay A. Mordovtsev   +3 more
doaj   +1 more source

A Comparison of Frequency Pullability in Oscillators Using a Single AT-Cut Quartz Crystal and Those Using Two Single AT- Cut Crystals Connected in Parallel with a Series Load Capacitance or Series Load Inductance [PDF]

, 2006
Vojko Matko
openalex   +1 more source

Analysis of on‐chipGSGpads coupling effects on laterally‐coupled and double‐stacked inductors in the millimeter‐wave frequency regime [PDF]

, 2023
Ernest Smith Mawuli, Kai Kang
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Research and experimentation of an electrical fault detection system for inductors used in EV charging stations

Tạp chí Khoa học và Công nghệ
With the growing integration of electric vehicles (EVs) into daily life, the demand for reliable charging stations has significantly increased. Ensuring the electrical safety of these stations requires high-quality inductor components to maintain ...
Nguyen Dac Minh Triet, Le Hoai Nam
doaj   +1 more source

Position Sensorless Control of Switched Reluctance Motor with Consideration of Magnetic Saturation Based on Phase-Inductance Intersection Points Information [PDF]

, 2018
Hui Cai, Hui Wang, Mengqiu Li, Shiqi Shen, Yaojing Feng   +4 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

EXPERIMENTAL STUDY OF PROCESSES IN AN ATTRACTIVE-SCREEN INDUCTOR SYSTEM UNDER ADDITIONAL COIL INSERTION

Electrical engineering & Electromechanics, 2014
The article is devoted to experimental investigations of action of an additional coil inserted inside an inductor system with an attractive screen on induced current distribution in the work-piece and to determination of the coefficient of the solenoid ...
Yu.V. Batygin, E.A. Chaplygin, S.A. Shinderuk   +2 more
doaj  

Low-Loss Soft Magnetic Materials and Their Application in Power Conversion: Progress and Perspective

Energies
Amorphous and nanocrystalline alloys, as novel soft magnetic materials, can enable high efficiency in a wide range of power conversion techniques. Their wide application requires a thorough understanding of the fundamental material mechanisms, typical ...
Weiwang Wang, Jiaqi Fan, Changshen Li, Yue Yu, Anding Wang, Shengtao Li, Jinjun Liu   +6 more
doaj   +1 more source