Results 101 to 110 of about 43,950 (300)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Design of Coupled Inductor for Interleaved Boost Converter

This paper presents an analysis of coupled inductor for interleaved boost converter and the effect of coupled inductor on current ripple reduction and on load transient response time.
Kroičs, Kaspars, Bražis, Viesturs, Sirmelis, Uģis   +2 more
core  

Comparative analysis of active filters, inductor-capacitor and inductor-capacitor-inductor passive filters in reducing harmonics [PDF]

Control equipment at substations requires a rectifier to convert alternative current (AC)-direct current (DC) electric current to provide DC power for relays, motors for disconnector switches and power breaker switches, and telecommunications equipment ...
Mohamed, Nur Nabila, Siregar, Yulianta, Azhari, Naomi   +2 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

A Review of Engineering Techniques for CMOS On-Chip Inductor Design and Quality Factor Enhancement From MHz-to-GHz Frequency Domains

IEEE Access
This paper presents a comprehensive review of engineering techniques employed to enhance the quality factor (Q-factor) of silicon-based on-chip inductors across MHz-to-GHz frequency domains. The performance of CMOS on-chip inductors is often bottlenecked
Selvakumar Mariappan, Jagadheswaran Rajendran, Norhamizah Idros, Asrulnizam Abd Manaf, Narendra Kumar, Abdullah Alghaihab, Arokia Nathan, Binboga Siddik Yarman   +7 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Directly-Driven Inductor Wind Generator of Ring Construction

A design of the inductor generator for 12-kW wind plants is considered, with the rotational speed of 100 min-1, directly driven from a wind turbine without a step-up multiplier.
Pugačevs, Vladislavs, Manonovs, Muhabats, Ribickis, Leonīds, Levins, Nikolajs   +3 more
core  

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Inductor Generator with the Cantilever Rotor

The object of research is a like-polar inductor generator with two stator coaxial cores quick-response rotor placed between. There are some recommendations to choose tooth zone parameters from the standpoint of magnetic pulsations and noise suppression ...
Pugačevs, Vladislavs, Petrovs, Sergejs, Ribickis, Leonīds, Greivulis, Jānis   +3 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source