Results 131 to 140 of about 144,167 (351)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Инженерные технологии и системыIntroduction. Induction heating is a preferred heating technique for industrial, medical and consumer systems, because it has a number of advantages over traditional heat transfer methods. The advantages include energy efficiency, heating rate, safety of
Evgeny N. Neverov +4 more
doaj +1 more source
Novel Floating General Element Simulators Using CBTA [PDF]
, 2012 In this study, a novel floating frequency dependent negative resistor (FDNR), floating inductor, floating capacitor and floating resistor simulator circuit employing two CBTAs and three passive components is proposed.
Ayten, Umut Engin +3 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
LA PARTICIPACIÓN DEL EXTRANEUS EN EL DELITO FISCAL [PDF]
Crónica Tributaria, 2018 En el presente artículo se analizan las diversas formas de participación en el delito contra la Hacienda Pública, de una parte, la autoría corresponde al obligado tributario, al ser el delito fiscal un delito especial propio, de otro lado, es posible la ...
Carlos David Delgado Sancho
doaj
Radioisotope thermal generator (RTG) power conditioner [PDF]
, 1974 New regulator: (a) permits operation with high-impedance radioisotope thermal generators at conversion efficiencies typically above 90%; (b) does not require input filtering; (c) eliminates current spiking; and (d) is simple, efficient, and reliable ...
Stacey, W. S.
core +1 more source
Field variation of the rf penetration depth and its effect on kinetic inductance in Bi2Sr2CaCu2Ox microstrip transmission lines [PDF]
, 1991 D. P. Byrne, R. Kwor, T. S. Kalkur
openalex +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source