Results 101 to 110 of about 176,937 (351)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Analysis and Optimization of Multi-Winding Toroidal Inductors for Use in Multilayered Technologies

IEEE Access, 2019
The aim of this paper is to compare the performance of planar toroidal inductors and circular spiral inductors in multilayered technologies, in terms of achievable inductance density.
N. Vidal, J. M. Lopez-Villegas, Jesus A. Del Alamo   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Designing power inductors: practical solutions

, 2011
An overview of losses and thermal aspects if power inductors is given. Most of the time core losses are given only for sine square wave, but users use it in square waves. Also bulk currents affect losses in larger inductors.
Van den Bossche, Alex, Van den Bossche, AlexTW08801000552755F42033C8-F0ED-11E1-A9DE-61C894A0A6B4   +1 more
core  

Fan-Out-Package-Embedded Coupled Inductors for Integrated Voltage Conversion

, 2020
In this paper, novel fan-out-package-embedded coupled inductors are proposed and demonstrated for integrated voltage conversion. The coupled inductors have two interleaved thick windings embedded in a silicon-based fan-out package and surrounding an ...
Fang, Xiangming, Wu, Rongxiang, Ding, Yixiao, Sin, Johnny K.O.   +3 more
core   +1 more source

DC/AC Stage Parameters Design Method for Dual‐Mode Control DC/DC‐DC/AC Converter System

IET Power Electronics
Recently, a DC/DC–DC/AC converter system using dual‐mode control to increase efficiency has been actively studied by many researchers. Due to the similar maximum voltage and current stress of switches for dual‐mode control and traditional two‐stage ...
Di Kang, Hongliang Wang, Yang Jiang, Yibo Si, Xi Gui, Xiaonan Zhu, Xiumei Yue   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Modeling of Mutual Coupling between Inductors

This paper is devoted to EMI filter inductor modeling and mutual coupling modeling between two inductors positioned on PCB. 3D inductor models are developed and modeled in CST MWS.
Ašmanis, Aivis, Ašmanis, Gundars, Ribickis, Leonīds, Stepins, Deniss   +3 more
core  

Synthetic microwave inductors in SOI technology

, 1997
One of the most promising approaches in the field of active filtering has been the replacement of conventional passive resonators with active resonators that are based on high frequency inductance-simulating-circuits. For the first time the possibilities
Raskin, Jean-Pierre, Eggermont, J.-P., Vanhoenacker-Janvier, Danielle, Colinge, Jean-Pierre, 1997 IEEE International SOI Conference   +4 more
core   +1 more source