Results 21 to 30 of about 386,482 (263)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Strengthening the Industrial Foundation: Advancing the Industrial Foundation Re-engineering Project and Winning the Campaign for Industrial Foundation Upgrading [PDF]

中国工程科学
A strong industrial foundation is crucial for developing new-quality productive forces and strengthening the manufacturing sector in China. It also serves as an industrial cornerstone for establishing self-reliant industrial and supply chains ...
Yongxiang Lu, Ji Zhou, Xuedong Chen, Yong Gan, Zheng You, Gang Zhang, Xianming Qu, Yuan Xue, Minghao Zhu, Xiaoying Yang, Jiyuan Zang, Yishana Gu   +11 more
doaj   +1 more source

Productivity Improvement through Line Balancing by Using Simulation Modeling [PDF]

Journal of Optimization in Industrial Engineering, 2020
The typical problems facing garment manufacturers are long production lead time, bottlenecking, and low productivity. The most critical phase of garment manufacturing is the sewing phase, as it generally involves a number of operations or for the simple ...
Aregawi Yemane, Gebremedhin Gebremicheal, Teklewold Meraha, Misgna Hailemicheal   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A gap study between industry expectations and current competencies of bachelor’s degree graduates in industrial engineering in Thailand 4.0 era: A case study of industrial engineering graduates of Khon Kaen University

Cogent Education, 2022
The purpose of this research is to study the gap between industry expectations and the current competencies of bachelor’s degree industrial engineering graduates in Khon Kaen University in Thailand 4.0 era so that the research results of this study may ...
Nattariga Chaengpromma, Sirorat Pattanapairoj   +1 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Identification and analysis of research trends in industrial engineering in the papers published between January 2012 to January 2015

آموزش مهندسی ایران, 2015
In the recent decades, amount of researches in the field of industrial engineering grew increasingly which makes hard to find a new area in this field. Indeed it needs extensive searches on the many published papers related to the field.
Abdullah Aghaei, Mojtaba Hajian Heydari
doaj   +1 more source

Operation Principles of the Industrial Facility Infrastructures Using Building Information Modeling (BIM) Technology in Conjunction with Model-Based System Engineering (MBSE)

Applied Sciences, 2023
The current industrial facility market necessitates the digitization of both production and infrastructure to ensure compatibility. This digitization is presently accomplished using Building Information Modeling and digital twin technologies, as well as ...
Nikolai Bolshakov, Xeniya Rakova, Alberto Celani, Vladimir Badenko   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source