Results 41 to 50 of about 2,740,951 (332)
A perspective on the economic valorization of gene manipulated biotechnology: Past and future
Biotechnology Reports, 2015 Three distinct fields of gene manipulated biotechnology have so far been economically exploited: medical biotechnology, plant biotechnology and industrial biotechnology.
Mirjam Knockaert +3 more
doaj +1 more source
Grand Research Challenges for Sustainable Industrial Biotechnology.
Trends in Biotechnology, 2019 Future manufacturing will focus on new, improved products as well as on new and enhanced production methods. Recent biotechnological and scientific advances, such as CRISPR/Cas and various omic technologies, pave the way to exciting novel ...
A. Straathof +6 more
semanticscholar +1 more source
Organic Acid Production by Yeast Yarrowia lipolytica: A Review of the Last Five Years of Research
FermentationThe commercial significance of organic acids is extremely high. Due to their chemical properties, organic acids can be used both as building blocks and as individual compounds with enormous annual production.
Svetlana V. Kamzolova
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Microbial Cell Factories / Yeast biotechnology: teaching the old dog new tricks [PDF]
, 2014 Yeasts are regarded as the first microorganisms used by humans to process food and alcoholic beverages. The technology developed out of these ancient processes has been the basis for modern industrial biotechnology.
Gasser, Brigitte +2 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Industrial Biotechnology [PDF]
Biotechnology Journal, 2012 AbstractCover illustrationIndustrial biotechnology. Renewable biomass can be used as a raw material for the production of various chemicals, fuels and materials in a cost‐effective manner by employing metabolically engineered high performance microorganisms.
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Solid-State Metalloproteins—An Alternative to Immobilisation
Molecules, 2016 This commentary outlines a protein engineering approach as an alternative to immobilisation developed in our laboratory. We use a recombinant silk protein into which metal active sites can be incorporated to produce solid-state metalloprotein materials ...
Trevor D. Rapson
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