Results 31 to 40 of about 320,841 (267)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Optimization of Super Plastic forming process parameters of Al 6061 alloy reinforced with SiC nano composites by Taguchi method [PDF]

EPJ Web of Conferences
This study investigates the optimization of superplastic forming in aluminum alloy 6061 reinforced with 100 nm silicon carbide (SiC) nanoparticles, fabricated by use of the ultrasonic cavitation technique.
Saravanakumar K., Suyamburajan Vijay Ananth, Srinivasan Purushothaman, Pravinkumar K., Kumara K.M. Praveena, Yaragudri Hanamant, Gnanavel C., Madison Amanda Billy Berto   +7 more
doaj   +1 more source

Spatial growth and industry age [PDF]

Journal of Economic Theory, 2007
U.S. county data for the last 20 or 30 years show that manufacturing employment has been deconcentrating. In contrast, the service sector exhibits concentration in counties with intermediate levels of employment. This paper presents a theory where local sectoral growth is driven by technological diffusion across space.
Desmet, Klaus, Rossi-Hansberg, Esteban
openaire   +4 more sources

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Enhancing urban sustainability through industrial synergy: A multidisciplinary framework for integrating sustainable industrial practices within urban settings – The case of Hamadan industrial city

Open Engineering
This study conducts an in-depth analysis of the interplay between sustainable industrial growth and integrated industrial urban environments, proposing a novel paradigm for urban production.
Al-Asadi Asaad, Almusaed Amjad, Al-Asadi Fatima, Almssad Asaad   +3 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Analysing industrial growth in various cities in KwaZulu-Natal, South Africa

Journal of Economic and Financial Sciences, 2018
This article investigates the industrial success of various cities in KwaZulu-Natal, South Africa. It assesses the hypothesis that knowledge spillovers are supportive of industrial growth at the city level.
Clive E. Coetzee, Ewert P.J. Kleynhans
doaj   +1 more source

Industrial growth and technological prospects

Journal of New Economy, 2022
For Russia, technological prospects of industrial growth come from Industry 4.0. The possibilities for their realisation depend on the combination of labour and fixed capital.
Oleg S. Sukharev
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source