Results 51 to 60 of about 76,273 (302)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The Role of Low-Cost Digital Solutions in Supporting Industrial Sustainability [PDF]

Small and medium enterprise (SME) manufacturers are impeded from participating in sustainability initiatives using new technologies due to the high cost and the lack of clarity on where to start.
McFarlane D., Brooks S., Price Thomas K., Mukherjee A., Macchi M., Salter L., Abubakar A. S., Hawkridge G., Negri E., Tasnim AHmed., Yilmaz G., Evans S.   +11 more
core   +4 more sources

Climate Change and Industry: A Systematic Literature Review and Bibliometric Insights on Mitigation and Adaptation

World
Climate change is transforming industrial systems globally, both by exposing them to increasing environmental risks and by positioning them as key players in worldwide mitigation and adaptation efforts.
Veena P. Saraswathy, Biju Terrence, Umaru Kargbo, Timothy B. Palmer   +3 more
doaj   +1 more source

Consumer Preference between Fire Risk and Chemical Risk for Home Appliances Containing Flame Retardants in Plastic Parts

Safety, 2019
A questionnaire survey was conducted to explore consumer preference between fire risk and chemical risk, with a focus on electric and electronic home appliances whose plastic parts either contain or do not contain flame retardants (FRs).
Kiyotaka Tsunemi, Akemi Kawamoto, Kyoko Ono   +2 more
doaj   +1 more source

Financial Sustainability in Austrian Industrial Companies

Tehnički Glasnik, 2022
The Green Deal published by the European Commission in 2019 pursues the goal of a climate-neutral continent. Its guidelines cover sustainable finance, industry, and energy supply, among other areas.
Claudia Brandstätter, Marina Schober, Daniela Wilfinger   +2 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Sustainability Design in Industry and Academia

2024 10th International Conference on ICT for Sustainability (ICT4S)
Sustainability design involves the design of sustainable software systems. There is a growing need to integrate sustainability issues into software development; therefore, many approaches have been developed in recent years. A widely used approach for sustainability design, the Sustainability Analysis Framework (SusAF), is applied in three cases, two ...
Chasanidou, Dimitra, Krogstie, John, Boletsis, Costas, Gasparini, Andrea Alessandro   +3 more
openaire   +2 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source