Results 111 to 120 of about 44,090 (281)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

From Building Information Modeling to Building Energy Modeling: Optimization Study for Efficient Transformation

Buildings
The conversion from building information modeling (BIM) to building energy modeling (BEM) based on the industry foundation classes (IFC) data standard is a crucial step for efficient building energy design and energy performance analysis.
Na An, Xin Li, Huaqiu Yang, Xiufeng Pang, Guoheng Gao, Ding Ding   +5 more
doaj   +1 more source

Integrated asset management of water and wastewater infrastructure systems : borrowing from industry foundation classes

, 2015
Viewing water and wastewater infrastructure systems from a network or functional viewpoint down to an individual component goes hand in hand with life-cycle management.
Unger, Andre J. A., Haas, Carl T., Ganjidoost, Amin, Knight, Mark A.   +3 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Enriching Building Information Modeling Models through Information Delivery Specification

Buildings
The efficient acquisition and dissemination of information are crucial in building information modeling (BIM). Current BIM models face significant challenges, including inadequate modeling techniques, poorly defined information requirements, and low ...
Giancarlo de Marco, Cinzia Slongo, Dietmar Siegele   +2 more
doaj   +1 more source

An assessment of Industry Foundation Classes data schema applied to bridge models in the context of brazilian infrastructure

A indústria da construção civil é caracterizada por alto nível de fragmentação. Um único projeto pode demandar inúmeras soluções (modelos Building Information Modeling – BIM), que são desenvolvidas por diversos atores e suas respectivas ferramentas ...
Antunes, Maria Luisa Ribeiro
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Assessment of global warming potential from on-site construction processes (module A5): a pilot building case study

Frontiers in Built Environment
The building construction industry is under tremendous pressure to cut down on greenhouse gas (GHG) emissions as upfront embodied carbon emissions are substantial contributors to the carbon footprint of the built environment.
Abhishek Singh Kushwaha, Amit B. Mahindrakar   +1 more
doaj   +1 more source

An Ontology Web Language Notation of the Industry Foundation Classes

, 2005
In this paper we describe and discuss an OWL notation of IFCs, its advantages over generic XML schema representation, its various fields of possible application, and our implementation of it in a multi-agent framework.
Beetz, J., Leeuwen, van, J.P., Vries, de, B.   +2 more
openaire   +1 more source