Results 71 to 80 of about 42,352 (253)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

An Approach to Automatic Building Information Modeling-Based Generation of Finite Element Models of Different Complexity and Finite Element Dimensionality

Buildings
(1) The presented paper proposes an approach to the BIM-based generation of FE models of different complexity and FE dimensionality. This is particularly important as different FE models are needed to assess various structural or material limit states ...
Iryna Rudenko, Yuri Petryna
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

AI-Driven IFC Processing for Automated IBS Scoring

Algorithms
The assessment of Industrialized Building System (IBS) adoption in construction projects—a critical metric for evaluating prefabrication levels and construction modernization—remains largely manual, time-intensive, and prone to inconsistencies, with ...
Annamária Behúnová, Matúš Pohorenec, Lucia Ševčíková, Marcel Behún   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Review on parametric building information modelling and forward design approaches for sustainable bridge engineering

Discover Applied Sciences
This paper reviewed the application of parametric building information modelling (BIM) in bridge engineering, highlighting its contributions to improving workflows, fostering interdisciplinary collaboration, enhancing interoperability, and optimizing ...
Shanshan Wu, Mohd Zamri Ramli, Shek Poi Ngian, Gen Qiao, Bolin Jiang   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Digital twin modeling method based on IFC standards for building construction processes

Frontiers in Energy Research
Intelligent construction is a necessary way to improve the traditional construction method, and digital twin can be a crucial technology to promote intelligent construction.
Chengyuan Dai, Chengyuan Dai, Ke Cheng, Bangxun Liang, Xinyi Zhang, Qizhou Liu, Zengqin Kuang   +6 more
doaj   +1 more source

METACOMPILAÇÃO DE CLASSES PARA ACESSO A MODELOS IFC E SUGESTÕES PARA CRIAÇÃO DE CLASSES PARA ACESSO EM ALTO NÍVEL

Gestão & Tecnologia de Projetos, 2009
As Industry Foundation Classes, IFC, são um esquema criado em EXPRESS para descrição e transmissão inequívoca de informações na indústria da construção.
Cervantes AYRES Filho, Sérgio Scheer
doaj   +1 more source