Results 41 to 50 of about 73,838 (265)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Measuring influencing factors affecting mortality rates during the COVID-19 pandemic

Global Health Action
Background The COVID-19 pandemic has revealed clear deficiencies in global public health policies and healthcare systems when confronted with the emergence of a novel and deadly infectious disease.
Jih-Shong Wu, Kuo-Kuang Huang
doaj   +1 more source

СУБЪЕКТЫ ИНСТИТУЦИОНАЛИЗАЦИИ СОЦИАЛЬНО-ЭКОНОМИЧЕСКОЙ АКТИВНОСТИ МОЛОДЕЖИ В ПОСТ СОВЕТСКОЙ РОССИИ

Sovremennye Issledovaniâ Socialʹnyh Problem, 2015
Важной целью социальных исследований является изучение социализации молодежи и развития гражданской активности в пост советской России. Социально-экономическая и политическая ситуация, традиционные формы управления влияют на социокультурные установки и ...
Ekaterina Nikolaevna Vasileva, Evgenii Sergeevich Vasilev   +1 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

How Does the Competitiveness Index Promote Foreign Direct Investment at the Provincial Level in Vietnam? An Integrated Grey Delphi–DEA Model Approach

Mathematics, 2023
Foreign direct investment (FDI) is an important factor in building a strong economy for a country, particularly in developing and emerging markets. Both domestic enterprises and policy makers have been motivated to attract FDI for the benefits of FDI ...
Phi-Hung Nguyen, Thi-Ly Nguyen, Hong-Quan Le, Thuy-Quynh Pham, Hoang-Anh Nguyen, Chi-Vinh Pham   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Inefficiency of Nash Equilibria [PDF]

Mathematics of Operations Research, 1986
It is shown that Nash Equilibria of smooth games generally tend to be inefficient in the Pareto sense.
openaire   +4 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Evaluation of Technical Efficiency in Exotic Carp Polyculture in Northern India: Conventional DEA vs. Bootstrapping Methods

Fishes, 2022
The paper adopts the conventional data envelopment analysis (DEA) and bootstrap procedure to analyze the technical efficiency, while tobit regression is applied to identify the factors affecting efficiencies of exotic fish polyculture in Jammu and ...
Hongzhi Zhang, Ubair Nisar, Yongtong Mu
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source