Results 61 to 70 of about 795,031 (294)

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

open access: yesAdvanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin   +11 more
wiley   +1 more source

Performance of probable dementia classification in a European multi-country survey

open access: yesScientific Reports
Feasibility constraints limit availability of validated cognitive assessments in observational studies. Algorithm-based identification of ‘probable dementia’ is thus needed, but no algorithm developed so far has been applied in the European context.
Matthias Klee   +2 more
doaj   +1 more source

Incidental inequity [PDF]

open access: yesEuropean Journal of Human Genetics, 2018
Incidental findings (also known as unsolicited or secondary findings) in genomics are genetic variants that are detected in an individual, yet are unrelated to the current diagnostic question and the phenotype (associated features) of the disorder for which that person is being investigated [1].
Nowak, K.J.   +3 more
openaire   +2 more sources

An Increasing Misalignment Between Crop Distribution and Environmental Resources Under Climate Change in China

open access: yesAdvanced Science, EarlyView.
Climate change reshapes the spatial alignment between crop production and environmental resources. Using multi‐source data and a crop model, integrated climatic, water, and soil endowments for maize and wheat are quantified and compared with harvest distributions.
Zheng'e Su   +13 more
wiley   +1 more source

How Factorial Survey Analysis Improves Our Understanding of Employer Preferences

open access: yesSwiss Journal of Sociology, 2019
Factorial Survey Analysis (FSA) is an analytical tool that presents respondents with fictional situations (“vignettes”) to be rated or judged. In this paper we study the use of FSA in labour market sociology, with a particular focus on employer-based ...
McDonald Patrick
doaj   +1 more source

Assessing the Potential Impacts of Innovative New Policy Proposals on Poverty in the United States

open access: yesRSF: The Russell Sage Foundation Journal of the Social Sciences, 2018
This article provides estimates of the potential anti-­poverty impacts of eight proposals presented in this double issue of RSF. Using the 2016 Annual Social and Economic Supplement to the Current Population Survey and the Census Bureau and Bureau of ...
Christopher Wimer   +2 more
doaj   +1 more source

Noise Fingerprints as a Quantitative Order Parameter for Polarization‐ and Defect‐Mediated Switching in Hafnia Ferroelectrics

open access: yesAdvanced Science, EarlyView.
Low‐frequency noise fingerprints in hafnia ferroelectrics provide a quantitative handle to resolve the long‐standing debate between polarization‐mediated and defect‐mediated switching. By tuning oxygen vacancy density via ALD O3 dose time and applying a physically constrained deconvolution, we extract bias‐resolved current fractions for both mechanisms
Ryun‐Han Koo   +8 more
wiley   +1 more source

A Renter’s Tax Credit to Curtail the Affordable Housing Crisis

open access: yesRSF: The Russell Sage Foundation Journal of the Social Sciences, 2018
To address the housing affordability crisis for low-income Americans, we argue for a refundable renter’s tax credit. The proposed credit would be delivered through the tax code, reach a broad segment of renters, and target those with high housing cost ...
Sara Kimberlin   +2 more
doaj   +1 more source

Inequality and Happiness: Are Americans and Europeans Different?

open access: yes, 2004
The answer to the question posed in the title is 'yes.' Using a total of 128,106 answers to a survey question about happiness,' we find that there is a large, negative and significant effect of inequality on happiness in Europe but not in the US.
A. Alesina, R. Tella, R. McCulloch
semanticscholar   +1 more source

Large-scale physical activity data reveal worldwide activity inequality

open access: yesNature, 2017
To be able to curb the global pandemic of physical inactivity and the associated 5.3 million deaths per year, we need to understand the basic principles that govern physical activity.
Tim Althoff   +5 more
semanticscholar   +1 more source

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