Results 51 to 60 of about 304,351 (269)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

The Use of Botulinum Toxin Type A in Esophageal Atresia Management: a Randomized, Controlled, Investigator-blinded Feasibility and Exploratory Trial in Piglets

Scientific Reports
Anastomotic strictures and leaks are severe complications following esophageal atresia (EA) repair. We hypothesized that esophageal injections of botulinum toxin type A (BTX-A) could mitigate these complications through muscle relaxation. This randomized,
Emma Svensson, Peter Zvara, Lars Hagander, Lars Rasmussen, Niels Qvist, Sören Möller, Henrik Daa Schrøder, Eva Kildall Hejbøl, Abdelkhalek Samy Abdelkhalek, Niels Bjørn, Súsanna Ákusdóttir Peterson, Kristine Cederstrom Larsen, Erik Omling, Martin Salö, Oliver J. Muensterer, Mark Bremholm Ellebaek   +15 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Pitch Perception in the First Year of Life, a Comparison of Lexical Tones and Musical Pitch

Frontiers in Psychology, 2017
Pitch variation is pervasive in speech, regardless of the language to which infants are exposed. Lexical tone is influenced by general sensitivity to pitch.
Ao Chen, Ao Chen, Catherine J. Stevens, René Kager   +3 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

‘We don’t ask for a luxury life, just basic things’: the experiences of mothers with babies in the UK asylum system

Wellbeing, Space and Society
UK asylum accommodation has repeatedly been indicted as failing to meet the needs of pregnant individuals, those caring for babies, and all children. Charity-sector staff supporting new mothers in the asylum system expressed concern that ill-equipped and
Sophie Lovell-Kennedy, Laura M. Grieve, Sarah Shemery, Vongayi Mufara, Tamima Lerkins, Benedicta Umanhonlen, Serveh Tamami, Fatma Abdilahi, Amanda Purdie, Helen L. Ball   +9 more
doaj   +1 more source

Infants’ Gaze Patterns for Same-Race and Other-Race Faces, and the Other-Race Effect

Brain Sciences, 2020
The other-race effect (ORE) can be described as difficulties in discriminating between faces of ethnicities other than one’s own, and can already be observed at approximately 9 months of age.
Anna Krasotkina, Antonia Götz, Barbara Höhle, Gudrun Schwarzer   +3 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Leveraging technological advances to assess dyadic visual cognition during infancy in high- and low-resource settings

Frontiers in Psychology
Caregiver-infant interactions shape infants' early visual experience; however, there is limited work from low-and middle-income countries (LMIC) in characterizing the visual cognitive dynamics of these interactions.
Prerna Aneja, Thomas Kinna, Thomas Kinna, Jacob Newman, Saber Sami, Joe Cassidy, Jordan McCarthy, Madhuri Tiwari, Aarti Kumar, John P. Spencer   +9 more
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source