Results 91 to 100 of about 170,327 (313)

A companion to the preclinical common data elements for rodent models of pediatric acquired epilepsy: A report of the TASK3‐WG1B, Pediatric and Genetic Models Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract Epilepsy syndromes during the early years of life may be attributed to an acquired insult, such as hypoxic–ischemic injury, infection, status epilepticus, or brain trauma. These conditions are frequently modeled in experimental rodents to delineate mechanisms of epileptogenesis and investigate novel therapeutic strategies.
Anna‐Maria Katsarou, Hana Kubova, Stéphane Auvin, Massimo Mantegazza, Melissa Barker‐Haliski, Aristea S. Galanopoulou, Christopher A. Reid, Bridgette D. Semple   +7 more
wiley   +1 more source

Malrotation and Midgut Volvulus in Children: Diagnostic Approach, Imaging Findings, and Pitfalls

Journal of the Korean Society of Radiology
Malrotation and midgut volvulus are surgical emergencies that commonly occur within the first month of life. The classic symptom is acute bilious vomiting, while nonspecific symptoms such as recurrent abdominal pain may be present in older children ...
Jeongju Kim, So-Young Yoo, Tae Yeon Jeon, Ji Hye Kim   +3 more
doaj   +1 more source

A Newborn Case of “c” Subgroup Mismatch Presenting with Severe Hemolysis and Anemia

Journal of Pediatric Research, 2017
Hemolysis and jaundice related to Rh incompatibility in the neonatal period has decreased substantially due to the widespread use of anti-D gammaglobulin in recent years.
Ezgi Yangın Ergon, Senem Alkan Özdemir, Rüya Çolak, Kıymet Çelik, Özgür Olukman, Şebnem Çalkavur   +5 more
doaj   +1 more source

Birth asphyxia as the major complication in newborns: Moving towards improved individual outcomes by prediction, targeted prevention and tailored medical care [PDF]

, 2011
Perinatal Asphyxia—oxygen deficit at delivery—can lead to severe hypoxic ischaemic organ damage in newborns followed by a fatal outcome or severe life-long pathologies.
CEBIOGLU M, GOLUBNITSCHAJA O, HERRERA-MARSCHITZ M, MORELLI M, YEGHIAZARYAN K   +4 more
core   +1 more source

INFECTIONS OF THE NEWBORNS: ETIOLOGY AND EPIDEMIOLOGY [PDF]

Romanian Journal of Pediatrics, 2008
Infections are a frecvent and important cause of morbidity and mortality in the newborn period. Infections in the newborn infant may be required in utero (congenital), at the terme/or birth (perinatal), or after birth and during the neonatal period ...
Valeriu Popescu
doaj   +1 more source

Hosts, microbiomes, and the evolution of critical windows

Evolution Letters, Volume 6, Issue 6, Page 412-425, December 2022., 2022
Abstract The absence of microbial exposure early in life leaves individuals vulnerable to immune overreaction later in life, manifesting as immunopathology, autoimmunity, or allergies. A key factor is thought to be a “critical window” during which the host's immune system can “learn” tolerance, and beyond which learning is no longer possible.
C. Jessica E. Metcalf, Burcu Tepekule, Marjolein Bruijning, Britt Koskella   +3 more
wiley   +1 more source

Identification of a Founder GLDN Variant Associated With “Lethal” Arthrogryposis in Nunavik Inuit: Implications for Obstetrical and Long‐Term Survivors' Management

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in GLDN have recently been associated with lethal congenital contracture syndrome 11 (LCCS11), a form of fetal akinesia deformation sequence (FADS) with high neonatal mortality. In this report, we describe five individuals from two Canadian Inuit families originating from different communities in Nunavik all affected with ...
Alexa McAdam, Yoko A. Ito, Marilyn Richard, Dan Spiegelman, Daniel Rochefort, Lan Xiong, Maryam Oskoui, David Zielinski, Guy A. Rouleau, Sirui Zhou, Care4Rare Canada Consortium, Kym M. Boykott, Isabelle De Bie   +12 more
wiley   +1 more source

A Case Study of a Female Infant With Primary Hypertrophic Osteoarthropathy Demonstrates That Early Initiation of Celecoxib Slows but Does Not Prevent Symptom Progression

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Primary Hypertrophic Osteoarthropathy (PHOAR1) is characterized by autosomal recessive loss of function variants in 15‐hydroxyprostaglandin dehydrogenase (HPGD) leading to digital clubbing, periostosis, pachydermia, and severe hyperhidrosis. HPGD catalyzes the first step of prostaglandin E2 (PGE2) degradation.
Kara Zehr, Morgan Buckley, Joshua W. Owens, Tomas Vanagunas, Patricia Vega Fernandez, Robert J. Hopkin, Amelle Shillington   +6 more
wiley   +1 more source

Nanopore Sequencing Solves an Elusive Case of Sotos Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Sotos syndrome is a rare genetic disorder characterized by distinctive facial features, including a broad and prominent forehead, dolichocephaly, and learning disabilities ranging from mild to severe intellectual impairment. Affected individuals often show overgrowth in height and head circumference over two standard deviations.
Pasquale Di Letto, Alberto Budillon, Sarah Iffat Rahman, Francesca Del Vecchio Blanco, Mariateresa Zanobio, Margherita Scarpato, Margherita Russo, Maria Elena Onore, Giulio Piluso, TUDP Study Group, Vincenzo Nigro, Sandro Banfi, Annalaura Torella, Manuela Morleo, Nicola Brunetti Pierri, Giancarlo Parenti, Carmine Spampanato, Giulio Piluso, Michele Pinelli, Giuseppina Vitiello, Angelo Selicorni, Milena Mariani, Cecilia Daolio, Valeria Capra, Andrea Accogli, Marcello Scala, Francesca Nardecchia, Serena Galosi, Mario Mastrangelo, Donatella Milani, Corrado Romano, Pinella Failla, Donatella Greco, Chiara Pantaleoni, Claudia Ciaccio, Stefano D’Arrigo, Antonietta Coppola, Teresa Mattina, Marcella Zollino, Domizia Pasquetti, Federica L. Erario, Albina Tummolo, Claudia Santoro, Anna Grandone, Livia Garavelli, Carla Marini, Stefania Bigoni, Carmelo Piscopo, Antonio Trabacca, Marta De Rinaldis, Vincenzo Nigro, Gioacchino Scarano, Annalaura Torella   +52 more
wiley   +1 more source

Primary health care in China: A decade of development after the 2009 health care reform

Health Care Science, Volume 1, Issue 3, Page 146-159, December 2022., 2022
After the launch of the historical Reform of the Medical and Health Care System in 2009, China's primary health care (PHC) system has witnessed significant progress and breakthroughs. In this review, we summarized published literature and official policies and synthesized data from the electronic registration information system of the National Health ...
You Wu, Zeyu Zhang, Ning Zhao, Yue Yan, Lina Zhao, Qi Song, Rong Ma, Changfeng Li, Jinyi Li, Suibin Liu, Xinran Bi, Zongjiu Zhang   +11 more
wiley   +1 more source