Results 121 to 130 of about 362,289 (308)

Model‐Informed Once‐Daily Dosing Strategy for Bedaquiline and Delamanid in Children, Adolescents and Adults with Tuberculosis

Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1292-1302, May 2025.
The complexity of the currently registered dosing schedules for bedaquiline and delamanid is a barrier to uptake in drug‐resistant tuberculosis treatment across all ages. A simpler once‐daily dosing schedule is critical to ensure patient‐friendly regimens with good adherence. We assessed expected drug exposures with proposed once‐daily doses for adults
Yu‐Jou Lin, Louvina E. van der Laan, Mats O. Karlsson, Anthony J. Garcia‐Prats, Anneke C. Hesseling, Elin M. Svensson   +5 more
wiley   +1 more source

Assistência pré-natal, baixo peso e prematuridade no Estado de São Paulo, 2000

Revista de Saúde Pública
OBJETIVO: São apresentados os dados da evolução histórica da taxa de mortalidade infantil e neonatal por peso ao nascer e duração da gestação, com o objetivo de mostrar sua importância e analisar o papel do número de consultas pré-natais entre outros ...
Samuel Kilsztajn, Anacláudia Rossbach, Manuela Santos Nunes do Carmo, Gustavo Toshiaki Lopes Sugahara   +3 more
doaj  

Pneumonia, an Unusual Initial Presentation of Neonatal Herpes Infection

Case Reports in Critical Care, 2019
Neonatal herpes simplex virus (HSV) infection is a life-threatening infection with high morbidity and mortality rates. Neonatal herpes, most commonly due to HSV type 2, is a multi-system disease; however, initial pulmonary presentation is extremely ...
Franck Kouadio, Gil Klinger
doaj   +1 more source

Assessment of newborn screening in the public health system of a municipality in northern Rio Grande do Sul

Clinical and Biomedical Research, 2018
Introduction: Newborn screening allows the screening of diseases that are still in the asymptomatic period and whose early diagnosis and treatment are associated with reduced infant morbidity and mortality.
Tássia Tonon, Elisa Sisti, Tatiéle Nalin, Ida Vanessa Doederlein Schwartz   +3 more
doaj  

Prenatal and Early Childhood Exposure to Antibiotics or Gastric Acid Inhibitors and Increased Risk of Epilepsy: A Nationwide Population‐Based Study

Clinical Pharmacology &Therapeutics, EarlyView.
Over 10 million children in the world have epilepsy, with an unknown cause in half of the cases. The gut microbiome has been associated with various neurological disorders, and certain drugs greatly disturb the microbiome. Our aim was to study the association of prenatal and childhood exposure (before the age of two) to antibiotics, proton pump ...
Unnur Gudnadottir, Ronny Wickström, Anna Gunnerbeck, Stefanie Prast‐Nielsen, Nele Brusselaers   +4 more
wiley   +1 more source

Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny.

Immunity, 2017
T. Kollmann, B. Kampmann, S. Mazmanian, A. Marchant, O. Levy   +4 more
semanticscholar   +1 more source

Populations Addressed in Vaccines Approved via the European Medicines Agency

Clinical Pharmacology &Therapeutics, EarlyView.
Therapeutic and prophylactic agents require robust evidence before patient use. Randomized controlled trials are essential for evaluating safety and efficacy but often exclude specific populations that are also targets for the intervention. This study assessed which populations are included in vaccine registration studies and/or addressed in label ...
Débora D. Gräf, Lukas Westphal, Jonathan Kimmelman, Christine E. Hallgreen   +3 more
wiley   +1 more source

Predicting Maternal and Fetal Exposures of Elexacaftor–Tezacaftor–Ivacaftor during Pregnancy through Physiologically Based Pharmacokinetic Models

Clinical Pharmacology &Therapeutics, EarlyView.
The use of elexacaftor/tezacaftor/ivacaftor (ETI) has been associated with increased fertility in women with cystic fibrosis (CF) and is increasingly used during pregnancy to support both maternal and fetal health. However, little is known about the pharmacokinetics (PK) of ETI during pregnancy, which is crucial for optimizing its efficacy and safety ...
Eunjin Hong, Mary F. Hebert, Emily Fay, Grant Turner, Patricia Eshaghian, Aaron Trimble, Peter S. Chung, Adupa P. Rao, Paul M. Beringer   +8 more
wiley   +1 more source

Biology and Management of Male‐Bodied Athletes in Elite Female Sports

Drug Testing and Analysis, EarlyView.
Graphical representation of the relationships of transgender and XY DSDF as male‐bodied athletes along the binary dimensions of biological sex. ABSTRACT The physical advantages in elite power sports that allow men to surpass women are derived from the experience of male puberty.
David J. Handelsman, Stéphane Bermon
wiley   +1 more source

A head start: The relationship of placental factors to craniofacial and brain development

Developmental Dynamics, EarlyView.
Abstract In recent years, the importance of placental function for fetal neurodevelopment has become increasingly studied. This field, known as neuroplacentology, has greatly expanded possible etiologies of neurodevelopmental disorders by exploring the influence of placental function on brain development.
Annemarie Jenna Carver, Martine Dunnwald, Hanna Elizabeth Stevens   +2 more
wiley   +1 more source