Results 201 to 210 of about 159,974 (289)

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

Does infant birthweight percentile identify mothers at risk of severe morbidity? A Canadian population-based cohort study. [PDF]

Matern Health Neonatol Perinatol
Ray JG, Berger H, Aoyama K, Cook JL, Aflaki K, Park AL.   +5 more
europepmc   +1 more source

Brain Activity Within Prefrontal Cortex: A Resting‐State fNIRS Comparative Study in High‐Functioning Autism Preschoolers and Typically Developed Peers

Journal of Biophotonics, EarlyView.
We applied functional near‐infrared spectroscopy (fNIRS) to detect the brain function within the prefrontal cortex in the 23 typically developing (TD) preschool children and 48 children with high‐functioning autism (HFA), aiming to observe the differences in brain function within the prefrontal cortex between the two groups.
Wenlong Song, Bin Zuo, Caiming Jiang, Zhicheng Zhang   +3 more
wiley   +1 more source

Investigating antibiotics in the NICU and patient safety. [PDF]

Front Cell Infect Microbiol
Lawrence SM, Wynn JL, Kimberlin DW, Cantey JB.   +3 more
europepmc   +1 more source

Saliva as a TDM matrix and its application in the model‐informed precision dosing

The Journal of Clinical Pharmacology, EarlyView.
Abstract This study reviews the main points of saliva as a therapeutic drug monitoring (TDM) matrix, its advantages and limitations, the methods of saliva sample collection and testing, the types of drugs in saliva TDM, and the methods of establishing saliva population pharmacokinetic (Pop PK) models, as well as summarizes the experiences and ...
Baohua Xu, Yujie Wen, Jinxia Lu, Maobai Liu, Xin Luo, Wei Huang, Helin Xie, Yu Cheng, Hongqiang Qiu, Xuemei Wu   +9 more
wiley   +1 more source

SPINAL DYSRAPHISM

The Turkish Journal of Pediatrics, 1965
K Till
doaj  

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

The Journal of Clinical Pharmacology, EarlyView.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima, Akihide Tsujimoto, Masako Saito, Jun Takeda, Makiko Natori, Satoshi Shoji   +5 more
wiley   +1 more source

A neonate with meconium peritonitis, first-trimester hepatitis A affected pregnancy: A case report. [PDF]

SAGE Open Med Case Rep
Figueroa Maisonet LL, Mayorga I, Reyes Bou Z, Rivera González JA, Ortiz Justiniano VN, Garcia Garcia I.   +5 more
europepmc   +1 more source

From PICU to NICU: Extrapolating Meropenem Exposure From Pediatric to Neonatal Intensive Care Patients

The Journal of Clinical Pharmacology, EarlyView.
Abstract We previously developed a population pharmacokinetic (PopPK) model for meropenem in pediatric intensive care unit patients accounting for effect of body size, maturation, and kidney function on clearance. This study aimed to extrapolate meropenem exposure to neonates and young infants using the pediatric PopPK model and to validate the ...
Ronaldo Morales Junior, Tomoyuki Mizuno, Wen Rui Tan, Kei Irie, Sonya Tang Girdwood   +4 more
wiley   +1 more source