Results 31 to 40 of about 112,890 (268)

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

Unusual large mass on aortic valve in an infant

Annals of Pediatric Cardiology, 2022
Mass on the aortic valve is extremely rare in children, and the differential diagnosis includes vegetation, thrombus, and primary cardiac tumors. A rise in infective endocarditis in infants is seen due to increasing survival of children with congenital ...
Lamk Kadiyani, Sivasubramanian Ramakrishnan, Mansi Verma, Sanjeev Kumar, Milind Hote   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The impact of age-specific childhood body-mass index on adult cardiometabolic traits: a Mendelian randomization study

Frontiers in Endocrinology
ObjectiveTo evaluate the causal relationship between childhood body-mass index (BMI) at different ages and adult cardiometabolic traits.MethodsWe retrieved genetic instrument variables (IVs) for exposures (standardized BMI at newborn, infant, toddler and
Jun Yang, Yalan Kuang, Xiaoyan Yang, Chunyang Li, Mei Qi, Ping Fu, Xiaoxi Zeng, Xiaoxi Zeng   +7 more
doaj   +1 more source

Human Breast Milk: From Food to Active Immune Response With Disease Protection in Infants and Mothers

Frontiers in Immunology, 2022
Breastfeeding is associated with long-term wellbeing including low risks of infectious diseases and non-communicable diseases such as asthma, cancer, autoimmune diseases and obesity during childhood.
Gatien A. G. Lokossou, Léonce Kouakanou, Anne Schumacher, Ana C. Zenclussen   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol

Frontiers in Immunology, 2023
Maternal immunisation, a low cost and high efficacy intervention is recommended for its pathogen specific protection. Evidence suggests that maternal immunisation has another significant impact: reduction of preterm birth (PTB), the single greatest cause
Michelle L. Giles, Michelle L. Giles, Michelle L. Giles, Stephen Cole, Jessica O’Bryan, Sushena Krishnaswamy, Sushena Krishnaswamy, Rym Ben-Othman, Nelly Amenyogbe, Mary-Ann Davey, Tobias Kollmann   +10 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Neurologic sequelae of severe chikungunya infection in the first 6 months of life: a prospective cohort study 24-months post-infection

BMC Infectious Diseases, 2021
Background Perinatally chikungunya infected neonates have been reported to have high rates of post-infection neurologic sequelae, mainly cognitive problems.
Roelof van Ewijk, Minke H. W. Huibers, Meindert E. Manshande, Ginette M. Ecury-Goossen, Ashley J. Duits, Job C. Calis, Aleid G. van Wassenaer-Leemhuis   +6 more
doaj   +1 more source