Results 71 to 80 of about 170,327 (313)

The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ

Advanced Science, EarlyView.
The placenta expresses much higher levels of PPARγ than fetal adipose tissue. Trophoblastic exosomes transport PPARγ into fetal preadipocytes via fetoplacental circulation and thus regulate adipogenic genes distinct from endogenous PPARγ. Compromised placental PPARγ leads to fetal adipogenesis deficiency and intrauterine growth restriction, reversible ...
Xiaofang Luo, Biao Huang, Ping Xu, Hao Wang, Baozhen Zhang, Li Lin, Jiujiang Liao, Mingyu Hu, Xiyao Liu, Jiayu Huang, Yong Fu, Mark D. Kilby, Rodney E. Kellems, Xiujun Fan, Yang Xia, Philip N. Baker, Hongbo Qi, Chao Tong   +17 more
wiley   +1 more source

A cry for help: Early detection of brain injury in newborns [PDF]

arXiv, 2023
Since the 1960s, neonatal clinicians have known that newborns suffering from certain neurological conditions exhibit altered crying patterns such as the high-pitched cry in birth asphyxia. Despite an annual burden of over 1.5 million infant deaths and disabilities, early detection of neonatal brain injuries due to asphyxia remains a challenge ...
arxiv  

Neural Plasticity and Hearing‐Speech Development in Children with Auditory Brainstem Implants for Congenital Hearing Loss Due to Severe Inner Ear Malformation

Advanced Science, EarlyView.
Data from a prospective cohort with 112 auditory brainstem implant users are analyzed. Younger age at implantation (<3 years), less severe inner‐ear malformation (common cavity, cochlear aplasia, and hypoplasia), and more intraoperative eABR evoked electrodes (≥60%) are associated with better hearing and speech outcomes.
Yu Zhang, Yongchuan Chai, Yiwen Zhang, Huan Jia, Zhaoyan Wang, Zhihua Zhang, Zhili Wang, Jie Chen, Xue Wang, Yun Li, Ying Chen, Hao Wu   +11 more
wiley   +1 more source

Medium‐chain Acyl‐COA dehydrogenase deficiency: Pathogenesis, diagnosis, and treatment

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
MCADD is a commonly inherited metabolic disease with serious implications for health outcomes, particularly in children, that may be successfully managed with proper intervention. In this review, we discuss the genetics, pathogenesis, clinical presentation, diagnosis, and treatments for Medium‐Chain Acyl‐CoA Dehydrogenase Deficiency (MCADD ...
Emily Mason, Charles C. T. Hindmarch, Kimberly J. Dunham‐Snary   +2 more
wiley   +1 more source

Can Zika Account for the Missing Babies?

Frontiers in Public Health, 2017
The Zika virus (ZIKV) spread rapidly in Brazil in 2015 and 2016. Rio de Janeiro was among the Brazilian cities which were hit the hardest, with more that a hundred thousand confirmed cases up to the end of 2016.
Flávio Codeço Coelho, Margaret Armstrong, Valeria Saraceni, Cristina Lemos   +3 more
doaj   +1 more source

SÍNDROME DE BART: RELATO DE CASO E REVISÃO

Residência Pediátrica, 2023
MAB, newborn male, e.t , gestational age of 37 weeks and 5 days. During his initial care, no changes were noted, except for skin lesions: cutaneous aplasia on limbs, back, inguinal region and mucous membranes, as well as bullous lesions and nail ...
Maria Paula Sandri Facchin, Mayara Reis de Oliveira, Mauren Seidl, Marina Helena Capra, Ana Carolina Vieira, Fabiana Rubbo de Melo, Jaqueline Reginatti   +6 more
doaj   +1 more source

Neurodevelopmental Age Estimation of Infants Using a 3D-Convolutional Neural Network Model based on Fusion MRI Sequences [PDF]

arXiv, 2020
The ability to determine if the brain is developing normally is a key component of pediatric neuroradiology and neurology. Brain magnetic resonance imaging (MRI) of infants demonstrates a specific pattern of development beyond simply myelination. While radiologists have used myelination patterns, brain morphology and size characteristics in determining
arxiv  

Improving Communication between Doctors and Parents after Newborn Screening [PDF]

, 2011
Background: Newborn screening (NBS) enables early treatment, and some consider it a natural vehicle for genetic screening. Bioethicists argue for caution since families of infants with carrier status can develop psychosocial complications.
Christopher, Stephanie, Collins, Jenelle, Eskra, Kerry, Farrell, Michael, Farrell, Philip M., Hoffman, Gary, Kennedy-Parker, Karen, La Pean, Alison, Panepinto, Julie, Tluczek, Audrey   +9 more
core   +2 more sources

Adrenal High‐Expressional CYP27A1 Mediates Bile Acid Increase and Functional Impairment in Adult Male Offspring by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) can induce dysfunction in adrenal steroid synthesis in adult male offspring. This study demonstrate that the mechanism is associated with the upregulation of fetal adrenal cholesterol 27 hydroxylase (CYP27A1)promoter region histone 3 lysine 27 acetylation (H3K27ac) levels and expression mediated by PDE through the ...
Jiangang Cao, Wen Hu, Yawen Chen, Aihemaitijiang Ailikaiti, Ziyi Zhang, Lingbo Rong, Hong Yu, Hui Wang   +7 more
wiley   +1 more source

Anesthetic management of neonates undergoing diagnostic and therapeutic cardiac catheterization: a systematic literature review [PDF]

Revista Brasileira de Anestesiologia
Background: Several interventional cardiology procedures are required in neonates with congenital heart disease. Interventional cardiology procedures have a higher risk of cardiac arrest compared to other interventions.
Lina M. Valencia-Arango, Angélica P. Fajardo-Escolar, Juan C. Segura-Salguero, Santiago Sáenz-Quispe, Carolina Rincón-Restrepo, Adriana Posada, Vivian Ronderos, Ana H. Perea-Bello   +7 more
doaj   +4 more sources