Results 131 to 140 of about 342,862 (291)

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

A study to determine the effectiveness of cleanliness measures by mothers in preparation for handling of feeding their infants [PDF]

, 1958
Thesis (M.S.)--Boston ...
Lau, Evelyn Babs
core   +1 more source

Translation of a physiologically‐based pharmacokinetic model for dabigatran etexilate to the design of a safety and efficacy study in post‐partum women

British Journal of Clinical Pharmacology, EarlyView.
Aims To translate a PBPK model developed for the direct oral anticoagulant, dabigatran etexilate, the prodrug of dabigatran, based on data obtained from healthy men to healthy non‐pregnant, pregnant and post‐partum women. To evaluate safety and efficacy of dabigatran etexilate in post‐partum women using simulations and design a future clinical study to
Kayode Ogungbenro, Lorna Aucott, Farhad Kamali, Paul Ayuk   +3 more
wiley   +1 more source

Secular trends in infant mortality by age-group and avoidable components in the State of São Paulo, 1996–2012

Revista Paulista de Pediatria
Objective: To describe trends and composition of infant mortality rate in the State of São Paulo, from 1996 to 2012. Methods: An ecological study was conducted, based on official secondary data of births and infant deaths of residents in São Paulo, from
Kelsy Catherina Nema Areco, Tulio Konstantyner, José Augusto de Aguiar Carrazedo Taddei   +2 more
doaj   +1 more source

Performance of a Nonelectric Infant Warmer in Rwandan Health Centers. [PDF]

, 2019
Background. Neonatal hypothermia remains a challenge in resource-limited settings. Methods. We conducted a prospective mixed-methods cohort study in rural Rwandan health centers to assess the performance of an infant warmer we designed for low-resource ...
Feldman, Henry A, Gadgil, Ashok, Hansen, Anne, Kateera, Fredrick, Kubwimana, Marthe, May, Leana, Nahimana, Evrard, Nshimyiryo, Alphonse, Nyishime, Merab, Schoen, Natalie   +9 more
core  

Population pharmacokinetics of levofloxacin in breastmilk in patients with rifampicin‐resistant tuberculosis

British Journal of Clinical Pharmacology, EarlyView.
Levofloxacin is a widely used antibiotic included in rifampicin‐resistant tuberculosis (RR‐TB) treatment. Data describing levofloxacin concentrations in breastmilk and infant exposure are limited. We analysed data from two South African studies of breastfeeding women receiving levofloxacin (750–1000 mg daily) for RR‐TB.
Sharon Sawe, Lufina Tsirizani, Buyisile Mkhize, Lubbe Wiesner, Gary Maartens, Francesca Conradie, Richard Court, Marian Loveday, Catriona Waitt, Paolo Denti   +9 more
wiley   +1 more source

Pharmacokinetic modelling of intravenous immunoglobulin in children with primary immunodeficiencies and secondary antibody deficiencies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Children with primary immunodeficiency (PID) and secondary antibody deficiency (SAD) often require immunoglobulin replacement therapy due to low plasma immunoglobulin G (IgG) levels and recurrent infections. Existing pharmacokinetic models for immunoglobulin in PID patients predominantly focus on adults, with limited attention to ...
Iek Leng Cheng, Zhong Hui Huang, Austen Worth, Claire Booth, Joseph F. Standing   +4 more
wiley   +1 more source

Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment

Nature Communications
We evaluated associations among exposure to prenatal phthalate metabolites, perturbations of the newborn metabolome, and infant neurobehavioral functioning in mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort during 2016–
Susan S. Hoffman, Ziyin Tang, Anne Dunlop, Patricia A. Brennan, Thompson Huynh, Stephanie M. Eick, Dana B. Barr, Blake Rushing, Susan L. McRitchie, Susan Sumner, Kaitlin R. Taibl, Youran Tan, Parinya Panuwet, Grace E. Lee, Jasmin Eatman, Elizabeth J. Corwin, P. Barry Ryan, Dean P. Jones, Donghai Liang   +18 more
doaj   +1 more source

Potential of a digital parenting app to support parents of toddlers: Relations between the intensity of app use, language‐related parental self‐efficacy and the home literacy environment

British Educational Research Journal, EarlyView.
Abstract The home literacy environment (HLE) has a considerable influence on children's language development. How parents perceive their own parenting abilities (e.g., how well they encourage their children's language development) is particularly important when it comes to guiding their children appropriately through different stages of development ...
Luisa Prokupek, Theresia Hummel, Sabine Blaurock, Franziska Cohen, Yvonne Anders   +4 more
wiley   +1 more source