CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Evinacumab, an angiopoietin‐like 3 inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C) in patients with homozygous familial hypercholesterolemia (HoFH). Herein, we report pharmacokinetic and efficacy analyses of evinacumab in < 5‐year‐old patients with HoFH.
Sébastien Bihorel +18 more
wiley +1 more source
Predictive Value of Postnatal Weight Gain Rate for Severe Retinopathy of Prematurity in Preterm Infants: A Retrospective Analysis. [PDF]
J Multidiscip HealthcWang J, Ma Q, Du F.
europepmc +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Early onset neonatal Group B Streptococcus (GBS) infection accounts for significant global morbidity and mortality. Intrapartum prophylaxis with benzylpenicillin is advised for women at high risk of having a baby affected by early onset GBS disease. Pregnancy‐related physiological changes can alter pharmacokinetics. To estimate the intrapartum
Bonniface Obura +6 more
wiley +1 more source
Associations between antibiotic exposure intensity, intestinal microbiome perturbations, and outcomes in premature neonates with bacteremia. [PDF]
J PerinatolHendricks H +5 more
europepmc +1 more source
State‐of‐the‐Art on Model‐Informed Drug Development Approaches for Pediatric Rare Diseases
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Pediatric rare diseases present unique challenges for drug development due to small patient populations, ethical constraints on clinical trial design, and limited prospectively defined natural history data. Model‐Informed Drug Development (MIDD) has emerged as a powerful paradigm to address these challenges by leveraging quantitative methods ...
Rajesh Krishna +4 more
wiley +1 more source
Advances in Atopic Dermatitis Treatment: From Pathogenesis to Natural Product‐Based Therapies
Phytotherapy Research, EarlyView.NPs improve atopic dermatitis mainly include flavonoids, phenols, glycosides, alkaloids, and others. ABSTRACT Atopic dermatitis (AD), a widespread and chronic inflammatory skin disorder, profoundly affects patients' quality of life, imposes significant psychological strain, and adds to the public health burden.
Xinyun Fan +8 more
wiley +1 more source
The optimal catheter duration in hypospadias repair: A systematic review
UroPrecision, EarlyView.Abstract Hypospadias is the most prevalent congenital anomaly of the penis, with surgical intervention being its only treatment option. There remains ongoing debate regarding the necessity, the type, and duration of urine diversion following hypospadias repair.
Yasmine Adel Mohammed +7 more
wiley +1 more source
Enabling discovery of the social determinants of health: using a specialized lens to see beyond the surface. [PDF]
J Med Libr AssocSheffield C +6 more
europepmc +1 more source
Chinese Clinical Practice Guidelines for Auditory Neuropathy (gCAN)
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Auditory neuropathy (AN) is an auditory disorder that affects the function of the auditory pathway. An increasing number of AN cases have been identified with the revelation of the underlying mechanisms, the advancements of diagnostic and detecting techniques.
Chinese Multi‐Center Research Collaborative Group on Clinical Diagnosis and Intervention of Auditory Neuropathy; Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Society of Otorhinolaryngology Head and Neck Surgery +43 more
wiley +1 more source
A retrospective cohort study of premature neonatal mortality rates and contributing factors in a tertiary referral NICU in Addis Ababa, Ethiopia from 2022 to 2023. [PDF]
Clin Epidemiol Glob HealthValentine GC +8 more
europepmc +1 more source