Results 111 to 120 of about 602,324 (304)
Clinical Pharmacology &Therapeutics, EarlyView.Pregnant and breastfeeding individuals are routinely excluded from clinical drug development, creating persistent evidence gaps in pharmacology, safety, and dosing. Despite mandatory contraception and pregnancy testing, unintended pregnancies occur, particularly during the development of central nervous system (CNS) medicines used by women of ...
Sam Schoenmakers +4 more
wiley +1 more source
Noise and the premature infant: Physiological effects and practice implications
, 2003 Premature infants in the neonatal intensive-care unit often are exposed to continuous loud noise. This excess auditory stimulation creates negative physiological responses, such as increased heart and respiratory rates and decreased oxygen saturation ...
core +1 more source
Zebrafish inversin mutants develop scoliosis in the absence of laterality defects
Developmental Dynamics, EarlyView.Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick +3 more
wiley +1 more source
National Sudden Infant Death Register: three year project: 1992-1994: interim report.
, 1992 Infant mortality in Western societies over the past 30 years has been declining. In Ireland the rate has fallen from 25 per 1,000 live births in 1961 to 8.2 per 1,000 live births in 1991.
Irish Sudden Infant Death Association.
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International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Studies assessing the validity of screening measures for avoidant/restrictive food intake disorder (ARFID) remain scarce. We evaluated the diagnostic performance and validity of an online, parent‐reported screening approach for ARFID in a population‐based sample of children.
Diana Friskson +6 more
wiley +1 more source
Infant mortality in Delaware: the need to improve maternal health and reduce premature births. [PDF]
, 2008 Delaware\u27s high infant mortality rate continues to be driven by an increasing number of premature births. Premature birth is a complex problem with both social and medical roots.
Paul. MD, David A
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Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Abnormal KCC2 expression and function in a mouse model of epilepsy and tuberous sclerosis complex
Epilepsia, EarlyView.Abstract Objective Drug‐resistant epilepsy is a common, severe manifestation of the genetic disorder tuberous sclerosis complex (TSC). Although significant mechanistic and therapeutic advances have been made in TSC, treatments for seizures remain largely ineffective.
Dongjun Guo +4 more
wiley +1 more source