Results 181 to 190 of about 1,324,038 (335)

New insights into applications of base editor in hereditary disorders

open access: yesInterdisciplinary Medicine, EarlyView.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai   +8 more
wiley   +1 more source

Understanding the Susceptibility of the Premature Infant to Necrotizing Enterocolitis (NEC)

open access: yesPediatric Research, 2008
C. Hunter   +3 more
semanticscholar   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

open access: yesInterdisciplinary Medicine, EarlyView.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang   +4 more
wiley   +1 more source

Review: microbial metabolites - a key to address gut inflammation and barrier dysfunction in the premature infant. [PDF]

open access: yesGut Microbes
Robertson KM   +5 more
europepmc   +1 more source

Pregnancy complicated by a large prolapsing cervical fibroid requiring antepartum vaginal myomectomy—A case report

open access: yes
International Journal of Gynecology &Obstetrics, EarlyView.
Samantha Taylor   +2 more
wiley   +1 more source

A Physiologically Based Modeling Approach to Evaluate Intravenous Levetiracetam Dosing in Term and Preterm Neonates

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Seizures are the most common neurologic emergency in neonates and are associated with significant morbidity and mortality. Current first‐line pharmacotherapy, phenobarbital, is associated with serious adverse effects, including impairment of the developing brain.
Alexis Johnson   +4 more
wiley   +1 more source

A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract A preterm and term neonate to adult (PTNA) maturation equation was introduced recently to describe the glomerular filtration rate maturation from birth to adulthood for neonates of varying gestational age. This study aims to evaluate the newly developed PTNA equation against common maturation approaches like allometric scaling (AS0.75), the ...
Yunjiao Wu   +11 more
wiley   +1 more source

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