Results 231 to 240 of about 219,424 (290)

Docosahexaenoic acid ameliorates autistic‐like behaviors by inhibiting oxidative stress and inflammatory response in neonatal maternal separation rats

open access: yesPediatric Discovery, EarlyView.
The JNK pathway and oxidative stress are activated, and pro‐inflammatory cytokines are increased in neonatal maternal separation (NMS) rats. While docosahexaenoic acid treatment suppresses the activation of JNK pathway and oxidative stress, and reduces pro‐inflammatory cytokines release, thereby improving autism‐like behavior induced by NMS.
Boqing Xu   +5 more
wiley   +1 more source

Comparison of Model‐Predicted and Observed Evinacumab Pharmacokinetics and Efficacy in Children Aged < 5 Years With Homozygous Familial Hypercholesterolemia

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Evinacumab, an angiopoietin‐like 3 inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C) in patients with homozygous familial hypercholesterolemia (HoFH). Herein, we report pharmacokinetic and efficacy analyses of evinacumab in < 5‐year‐old patients with HoFH.
Sébastien Bihorel   +18 more
wiley   +1 more source

CNS methylation classifiers may misclassify normal developing cerebellar cortex as medulloblastoma. [PDF]

open access: yesActa Neuropathol
Cotter JA   +6 more
europepmc   +1 more source

Pharmacokinetics of Intrapartum Benzylpenicillin: Insights Into Candidate Regimens to Prevent Early Onset Neonatal Group B Streptococcus Disease

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Early onset neonatal Group B Streptococcus (GBS) infection accounts for significant global morbidity and mortality. Intrapartum prophylaxis with benzylpenicillin is advised for women at high risk of having a baby affected by early onset GBS disease. Pregnancy‐related physiological changes can alter pharmacokinetics. To estimate the intrapartum
Bonniface Obura   +6 more
wiley   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

open access: yesSmall, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai   +5 more
wiley   +1 more source

Neonatal delirium: fact or fiction? A study protocol of a prospective, observational study at the Neonatal Intensive Care Unit (NICU). [PDF]

open access: yesBMJ Paediatr Open
Tijssen KA   +6 more
europepmc   +1 more source

Dynamics of gut resistome and mobilome in early life: a meta-analysis. [PDF]

open access: yesEBioMedicine
Bargheet A   +8 more
europepmc   +1 more source

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