Results 51 to 60 of about 500,299 (305)

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Tracking regional brain growth up to age 13 in children born term and very preterm

Nature Communications, 2020
In this longitudinal study, the authors tracked the course of brain development from birth to adolescence (age 13 years) and examined the effects of very preterm birth.
Deanne K. Thompson, Lillian G. Matthews, Bonnie Alexander, Katherine J. Lee, Claire E. Kelly, Chris L. Adamson, Rod W. Hunt, Jeanie L. Y. Cheong, Megan Spencer-Smith, Jeffrey J. Neil, Marc L. Seal, Terrie E. Inder, Lex W. Doyle, Peter J. Anderson   +13 more
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Salmonella enterica Serovars Typhi and Paratyphi A are avirulent in newborn and infant mice even when expressing virulence plasmid genes of Salmonella Typhimurium

Journal of Infection in Developing Countries, 2010
Background: Salmonella enterica serovars Typhi and Paratyphi A are human host-restricted pathogens. Therefore, there is no small susceptible animal host that can be used to assess the virulence and safety of vaccine strains derived from these Salmonella
Javier Santander, Roy Curtiss III
doaj   +1 more source

The Importance of a Healthy Microbiome in Pregnancy and Infancy and Microbiota Treatment to Reverse Dysbiosis for Improved Health

Antibiotics, 2023
Background: The microbiome of newborn infants during the first 1000 days, influenced early on by their mothers’ microbiome health, mode of delivery and breast feeding, orchestrates the education and programming of the infant’s immune system and ...
Herbert L. DuPont, Madeleine Mary Hines Salge   +1 more
doaj   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Real‐World Trends in Prenatal Antirheumatic Drug Utilization in Ontario, Canada: A Cross‐Sectional Time‐Series Analysis

Arthritis Care &Research, EarlyView.
Objective This study aimed to describe real‐world trends in preconception and prenatal use of antirheumatic drugs among pregnant individuals with rheumatic diseases in Ontario, Canada. Methods We conducted a time‐series analysis using repeated cross‐sectional data to examine annual patterns of disease‐modifying antirheumatic drug (DMARD) use among ...
Shenthuraan Tharmarajah, Swaleh Hussain, Sara J. T. Guilcher, Lisa M. McCarthy, Dharini Mahendira, Howard Berger, Mina Tadrous   +6 more
wiley   +1 more source

The effect of maternal common mental disorders on infant undernutrition in Butajira, Ethiopia: the P-MaMiE study. [PDF]

, 2010
BACKGROUND: Although maternal common mental disorder (CMD) appears to be a risk factor for infant undernutrition in South Asian countries, the position in sub-Saharan Africa (SSA) is unclear METHODS: A population-based cohort of 1065 women, in the third ...
Mark Tomlinson, Vikram Patel, Prince Martin, Atalay Alem, Fikru Tesfaye, Mesfin Aray, Worku Bogale, Tomlinson Mark, Abdulahi, Abdulreshid, Abdulahi Abdulreshid, Medhin, Girmay, Zufan Lakew, Abdulreshid Abdulahi, Marcus Hughes, Lakew Zufan, Charlotte Hanlon, Bogale Worku, Worku, Bogale, Alem, Atalay,, Hughes Marcus, Martin Prince, Prince, Martin, Lakew, Zufan, Hanlon Charlotte, Aray, Mesfin, Dewey Michael, Michael Dewey, Alem Atalay, Tesfaye, Fikru, Patel Vikram, Dewey, Michael, Alem, Atalay, Aray Mesfin, Patel, Vikram, Hanlon, Charlotte, Tesfaye Fikru, Hughes, Marcus, Girmay Medhin, Medhin Girmay, Tomlinson, Mark   +39 more
core   +1 more source

The Future of Research in Cognitive Robotics: Foundation Models or Developmental Cognitive Models?

Advanced Robotics Research, EarlyView.
Research in cognitive robotics founded on principles of developmental psychology and enactive cognitive science would yield what we seek in autonomous robots: the ability to perceive its environment, learn from experience, anticipate the outcome of events, act to pursue goals, and adapt to changing circumstances without resorting to training with ...
David Vernon
wiley   +1 more source

The effects of maternal and infant vitamin A supplementation on vitamin A status: a randomised trial in Kenya. [PDF]

, 2007
Postpartum vitamin A supplementation of mothers and infants is recommended, but the efficacy has been questioned. In this double-blind, placebo-controlled trial, Kenyan mother-infant pairs were randomised to maternal vitamin A (400,000 IU) or placebo 0 ...
D. L. Mwaniki, Marshall, T, Tedstone, A.E., Alusala, D., Luoba, A, Ayah, R.A., Magnussen, Pascal, Tedstone, AE, D. Alusala, Michaelsen, KF, Michaelsen, Kim Fleischer, Friis, H, Mwaniki, DL, Luoba, A., K. F. Michaelsen, P. Kaestel, Magnussen, P, A. Luoba, Alusala, D, R. A. Ayah, A. E. Tedstone, Friis, Henrik, Kaestel, P, Marshall, T., P. Magnussen, Ayah, RA, H. Friis, Mwaniki, D.L., T. Marshall, Kæstel, Pernille   +29 more
core   +1 more source