Results 241 to 250 of about 2,441,241 (423)

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

open access: yesAdvanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang   +8 more
wiley   +1 more source

ProteoSeeker: A Feature‐Rich Metagenomic Analysis Tool for Accessible and Comprehensive Metagenomic Exploration

open access: yesAdvanced Science, EarlyView.
ProteoSeeker is a new metagenomic analysis tool that accelerates protein discovery. By automating key steps, it reduces computational complexity and enables comprehensive dataset analysis, performing protein identification, screening based on user‐defined protein families, and taxonomic analysis.
Georgios Filis   +6 more
wiley   +1 more source

Romiplostim use in pregnant women with immune thrombocytopenia

open access: yesAmerican Journal of Hematology, Volume 98, Issue 1, Page 31-40, January 2023., 2023
Abstract Treatment for immune thrombocytopenia (ITP) in pregnancy is hampered by the lack of fetal safety evidence of maternally‐administered medications. The Pregnancy Surveillance Program (PSP) collected patient information from 2017–2020 for pregnancy, birth outcomes, and adverse events (AEs) for 186 women exposed to romiplostim from 20 days before ...
James B. Bussel   +7 more
wiley   +1 more source

LATS1/2 loss promote tumor immune evasion in endometrial cancer through downregulating MHC-I expression

open access: yesJournal of Experimental & Clinical Cancer Research
Background LATS1/2 are frequently mutated and down-regulated in endometrial cancer (EC), but the contributions of LATS1/2 in EC progression remains unclear.
Qianlan Yang   +6 more
doaj   +1 more source

A Biographical Sketch of an Infant [PDF]

open access: green, 1877
Charles Darwin
openalex   +1 more source

Multimodal Nanoplasmonic and Fluorescence Imaging for Simultaneous Monitoring of Single‐Cell Secretory and Intracellular Dynamics

open access: yesAdvanced Science, EarlyView.
This study leverages the complementary advantages of label‐free nanoplasmonic biosensing and multichannel fluorescence microscopy to develop a multimodal imaging system for real‐time, spatiotemporal monitoring of cellular activities at the single‐cell level.
Saeid Ansaryan   +5 more
wiley   +1 more source

Human milk lactoferrin variation in relation to maternal inflammation and iron deficiency in northern Kenya

open access: yesAmerican Journal of Human Biology, Volume 34, Issue 12, December 2022., 2022
Abstract Background Milk lactoferrin is a multi‐functional, iron‐binding glycoprotein with immunomodulatory effects, protecting infants against infectious diseases. Aims This study explored how maternal inflammation/infection and iron‐deficiency anemia (IDA) might influence human milk lactoferrin.
Masako Fujita   +3 more
wiley   +1 more source

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