Results 81 to 90 of about 75,477 (218)

Extrapolation and pharmacokinetic protocol design optimization for ceftriaxone as an exemplar for the development of antibiotics for children

British Journal of Clinical Pharmacology, EarlyView.
Aim Ceftriaxone is a cephalosporin commonly used for the treatment of acute, severe infections; however, there are conflicting data on its disposition properties in children, making it a suitable case study for the evaluation of the appropriateness of extrapolation approaches based on exposure matching principles for paediatric patients and exploring ...
Daniel Valente Neves, Umberto Villani, Salvatore D'Agate, Sean Oosterholt, Ricardo de Carvalho Cavalli, Fabio Carmona, Vera Lucia Lanchote, Oscar Della Pasqua   +7 more
wiley   +1 more source

Plasma and breast milk pharmacokinetics of suvorexant in healthy lactating women

British Journal of Clinical Pharmacology, EarlyView.
Aim This paper aims to evaluate the plasma and breast milk pharmacokinetics of suvorexant, an orexin receptor antagonist used to treat insomnia at a maximum dose of 20 mg, in healthy lactating women. Methods The paper reports on an open‐label Phase 1 study in 12 healthy lactating women.
Jacqueline McCrea, Andrew Litovsky, Prachi Wickremasingha, Nairita Ghosal, Brad Roadcap, Robert Valesky, Robin Lee, Leea D. Reed, Ming Wang, Wei Fang, Rebecca Wrishko   +10 more
wiley   +1 more source

Insights into Novel Infant Milk Formula Bioactives

Nutrition and Dietary Supplements, 2020
Jordan Skolnick,1 Claire Chou,1 John Miklavcic1,2 1Schmid College of Science and Technology, Chapman University, Orange, CA 92866, USA; 2School of Pharmacy, Chapman University, Irvine, CA 92618, USACorrespondence: John MiklavcicSchmid College of Science ...
Skolnick J, Chou C, Miklavcic J
doaj  

The global extent of polypharmacy in neonatal intensive care: A systematic review

British Journal of Clinical Pharmacology, EarlyView.
Aims Pharmaceutical treatment in the neonatal intensive care unit (NICU) is challenging, with neonates often receiving multiple drugs during hospitalization. Given their physiological immaturity, polypharmacy raises concerns about potential adverse effects, drug–drug interactions and the risk of supratherapeutic or subtherapeutic treatment.
Mia Finserås Bretun, Ditte Resendal Gotfredsen, Aase Merethe Raddum, Charlotte Vermehren, Jón Þór Trærup Andersen, Ulrik Lausten‐Thomsen, Christina Gade   +6 more
wiley   +1 more source

Population pharmacokinetics of levetiracetam in term neonates with hypoxic–ischemic encephalopathy and therapeutic hypothermia: The LEVNEONAT‐1 study

British Journal of Clinical Pharmacology, EarlyView.
Aim This study aimed to describe the pharmacokinetics (PK) of levetiracetam (LEV) in term neonates treated for neonatal seizures secondary to hypoxic–ischemic encephalopathy (HIE). Methods Fifteen neonates were included and received a loading dose ranging from 30 to 60 mg/kg followed by eight maintenance doses corresponding to one‐fourth of the loading
Léo Mimram, Moreno Ursino, Julie Leger, Emilie Bourrel‐Ponchel, Florence Flamein, Alexandra Chadie, Isabelle Guellec, Sarah Zohar, Vincent Jullien, Géraldine Favrais   +9 more
wiley   +1 more source

Common gastrointestinal symptoms in healthy infants receiving goat milk-based formula or cow’s milk-based formula: a double-blind, randomized, controlled trial

BMC Pediatrics
Objective To assess common gastrointestinal symptoms in healthy Brazilian infants receiving goat milk-based formula (GMF) compared to cow’s milk-based formula (CMF).
P. Maximino, L. van Lee, Yvonne N. Meijer-Krommenhoek, L. van der Zee, H. da Costa Ribeiro Junior   +4 more
doaj   +1 more source

Infant Feeding Practices and Their Association with Early-Life Nutrient Intake: Baseline Findings from the Baby-Act Trial

Dietetics
Introduction: This is a secondary cross-sectional analysis of participants’ baseline data from the Baby-Act Trial to compare energy and macronutrients intake by feeding type.
Cristina Palacios, Elvira Alvarez, Maria Gabriela Kallis, Yari Valle, Jeremy Pomeroy, Maribel Campos   +5 more
doaj   +1 more source

Trends and patterns of antipsychotic medication use during pregnancy: A population‐based study

British Journal of Clinical Pharmacology, EarlyView.
Aim The prescription of antipsychotic medication during pregnancy, particularly second‐generation antipsychotics, has increased in several countries in recent decades. This population‐based study investigated trends and patterns in antipsychotic medication use during pregnancy between 2011 and 2023 in Northern Ireland (NI), UK.
Dervla Quinn, Michael Donnelly, Neil Heron, Joseph Kane, Lisa Kent, Fionnuala Mone, Ciaran O'Neill   +6 more
wiley   +1 more source

Pistols and pride flags: How gender matters for boys in Welsh relationships and sexuality education

British Educational Research Journal, EarlyView.
Abstract School‐based relationships and sexuality education (RSE) is a site of intense discursive circulation around the concept of gender. In the 2020s, international RSE curricula are responding to increasing visibility and cognisance of gendered and sexual diversity among young people and attempting to address gender‐based inequities and violence ...
Max R. Ashton
wiley   +1 more source

Entrepreneurial Orientation and Supply Chain Sustainability: A Systematic Literature Review

Business Strategy and the Environment, EarlyView.
ABSTRACT In increasingly volatile global markets, firms must cultivate entrepreneurial and adaptive capabilities to sustain competitiveness and advance sustainability objectives. This study systematically reviews the intersection of Entrepreneurial Orientation (EO), Supply Chain Management (SCM) practices, and sustainability performance through the ...
Olivia Finnerty, Graham Heaslip, Simon Stephens, Roisin Lyons, George Onofrei   +4 more
wiley   +1 more source