Results 161 to 170 of about 5,062,923 (350)
Clinical Pharmacology &Therapeutics, EarlyView.Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor +12 more
wiley +1 more source
MEASURING RODS OF INFANT MORTALITY
American Journal of Public Health, 1921 A study of the vital statistics of infant mortality gives evidence that, irrespective of place, year or class, there are three determinable and measurable constituents of the varying rates. Such practical measurement would seem an evaluation of the relative importance of methods of combat.
openaire +3 more sources
A British Pharmacological Society Position Statement on Medications in Pregnancy and Lactation
British Journal of Clinical Pharmacology, EarlyView.
Agnesa Mustafa +14 more
wiley +1 more source
Model‐Informed Evaluation of Hydroxyurea Exposure During Lactation
Clinical Pharmacology &Therapeutics, EarlyView.Hydroxyurea is a cornerstone therapy for sickle cell anemia; however, evidence guiding its use during lactation remains limited. This study aimed to develop a population pharmacokinetic (PK) model to characterize hydroxyurea disposition in maternal plasma and breast milk, and to quantify infant exposure under clinically relevant breastfeeding scenarios.
Anhar Hosawi +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Pain and fever are common in pregnancy. Dipyrone is widely used in Europe, Latin America, and parts of Asia, but is banned in other countries due to concerns about agranulocytosis. Evidence on its safety in pregnancy remains limited and inconsistent. This study aimed to evaluate whether maternal dipyrone use during the first‐ and third‐trimesters is ...
Itamar Ben Shitrit +7 more
wiley +1 more source
Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access
Clinical Pharmacology &Therapeutics, EarlyView.Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian +5 more
wiley +1 more source
Evaluation of the Impact of the Mother and Infant Health Project in Ukraine [PDF]
This paper exploits a unique opportunity to evaluate the impact of the quality change in the labor and delivery services on maternal and infant health. Since basic medical care has been universally available in Ukraine, implementation of the Mother and ...
Olena Nizalova, Maria Vyshnya
core +2 more sources
Developmental Dynamics, EarlyView.Abstract The sea anemone, Nematostella vectensis, has been used as a model organism in developmental biology studies for many years. This estuarine species has the notable capacity to regenerate its full body plan from small pieces throughout life. Nematostella have been described as having a great degree of cellular plasticity.
Patrick A. Lewis +3 more
wiley +1 more source
Indian Journal of Community Medicine, 1987 A retrospective study was carried out during 1983-84 in the field practice area of Kasturba Medical College, Manipal to determine the infant mortality rate and the factors influencing it.
Chakladar B.K +3 more
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