Results 181 to 190 of about 1,226,813 (207)

Infantile Epileptic Encephalopathy with Hypsarrhythmia (Infantile Spasms/West Syndrome)

Journal of Clinical Neurophysiology, 2003
Infantile spasms is a unique disorder peculiar to infancy and early childhood. In this article, the clinical manifestations and electroencephalographic features of the disorder are described. The possible pathophysiologic mechanisms underlying infantile spasms and the relation of this disorder to other childhood encephalopathies are discussed. Finally,
Richard A, Hrachovy, James D, Frost
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Delays to care in infantile epileptic spasms syndrome: Racial and ethnic inequities

Epilepsia, 2023
AbstractObjectiveNon‐Hispanic (NH) Black children are less likely to receive a standard treatment course for infantile epileptic spasms syndrome (IESS) than White/NH children at pediatric tertiary care epilepsy centers in the United States. However, if inequities exist in time to diagnosis is unknown.
Christina Briscoe Abath, Nishtha Gupta, Aristides Hadjinicolaou, Stephanie Donatelli, Avantika Singh, Sabrina Merchant, Morgan E. Ryan, Meghann Soby, Christopher Ryan, Adrianne Katrina Nelson, John E. Maldonado Pacheco, Bo Zhang, David N. Williams, Christopher J. Yuskaitis, Chellamani Harini   +14 more
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Genetics of infantile epileptic spasms syndrome in China

Developmental Medicine & Child Neurology
https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16435
Zhao Xu, Zongpu Zhou, Genfu Zhang, Jiaxin Zhuang, Yufen Li, Shuang Wang, Siqi Hong, Dan Sun, Jiong Qin, Zhixian Yang   +9 more
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Electroclinical Landscape of Infantile Epileptic Spasms Syndrome

Indian Journal of Pediatrics
To elucidate the electroclinical characteristics of infantile epileptic spasms syndrome (IESS) and to determine any potential association among these with underlying etiologies and response to therapy.Sixty-eight, treatment-naive children with IESS underwent long-term video electroencephalogram (EEG) recording, which was used to characterize the ...
Pankaj Pal, Sandeep Negi, Jitupam Baishya, Priyanka Madaan, Arushi Gahlot Saini, Renu Suthar, Chirag Ahuja, Naveen Sankhyan, Jitendra Kumar Sahu   +8 more
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Effectiveness of vigabatrin for infantile epileptic spasm syndrome categorized by etiologies

Seizure: European Journal of Epilepsy
We aimed to assess the effectiveness of vigabatrin (VGB) in patients diagnosed with infantile epileptic spasm syndrome (IESS) and categorize these patients based on their etiologies.This retrospective study included patients diagnosed with IESS who exhibited epileptic spasms before the age of 2 years between January 1, 2015, and October 31, 2023 at ...
Hirokazu Takeuchi, Kenjiro Kikuchi, Rikako Takeda, Yuko Hirata, Ryuki Matsuura, Reiko Koichihara, Daiju Oba, Hirofumi Ohashi, Shin-ichiro Hamano   +8 more
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Identification and treatment of surgically-remediable causes of infantile epileptic spasms syndrome

Expert Review of Neurotherapeutics
Infantile epileptic spasms syndrome (IESS) is a common developmental and epileptic encephalopathy with poor long-term outcomes. A substantial proportion of patients with IESS have a potentially surgically remediable etiology. Despite this, epilepsy surgery is underutilized in this patient group.
Emma Macdonald-Laurs, Winston Dzau, Aaron E.L. Warren, Matthew Coleman, Cristina Mignone, Sarah E. M. Stephenson, Katherine B. Howell   +6 more
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Understanding the neurobiology of infantile epileptic spasms syndrome (IESS): A comprehensive review

Seizure: European Journal of Epilepsy
Infantile Epileptic Spasms Syndrome (IESS) is a developmental and epileptic encephalopathy of infantile-onset and is characterized by epileptic spasms and often a hypsarrhythmia pattern on interictal electroencephalogram. The neurobiology of IESS involves diverse factors, including genetics, neurochemical imbalances, structural impairments, metabolic ...
Abhinav Modgil, Zubin Singh Rana, Jitendra Kumar Sahu, Pradeep Punnakkal   +3 more
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Novel copy number variations and phenotypes of infantile epileptic spasms syndrome

Clinical Genetics
Abstract We summarize the copy number variations (CNVs) and phenotype spectrum of infantile epileptic spasms syndrome (IESS) in a Chinese cohort. The CNVs were identified by genomic copy number variation sequencing. The CNVs and clinical data were analyzed. 74 IESS children with CNVs were enrolled.
Miaomiao Cheng, Ling Bai, Ying Yang, Wenwei Liu, Xueyang Niu, Yi Chen, Quanzhen Tan, Xiaoling Yang, Qixi Wu, Han‐Qing Zhao, Yuehua Zhang   +10 more
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Whole Genome Sequencing in Developmental Epileptic Encephalopathy with Epileptic Spasms and Infantile Epileptic Spasms Syndrome with Unknown Etiology

Objective: This study aimed to evaluate the diagnostic yield of whole genome sequencing (WGS) in patients with developmental epileptic encephalopathy manifesting with epileptic spasms (DEE-ES) and infantile epileptic spasms syndrome (IESS) with unknown etiology, and to assess treatment outcomes of patients with and without a genetic diagnosis.Methods ...
Kullasate Sakpichaisakul, Rachata Boonkrongsak, Kantapon Trongkamolchai, Sirorat Suwannachote, Somjit Sri-udomkajorn, Navarat Rungteeranon, Chaiyos Khongkhatithum, Chanikhan Sattaporn, Thitiporn Fangsaad, Nareenart Iemwimangsa, Sommon Klumsathian, Bhakbhoom Panthan, Objoon Trachoo   +12 more
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Electrographic screening for infantile epileptic spasms syndrome in a single sleep–wake cycle

Epilepsia
Abstract Objective Infantile epileptic spasms syndrome (IESS) is a common and urgent diagnosis with seizure and nonseizure mimics. Evaluation with prolonged video–electroencephalography (EEG) can be time‐consuming and costly.
John A. Mason, Elizabeth Juarez‐Colunga, Kelly G. Knupp   +2 more
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