Results 111 to 120 of about 785,029 (297)
Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu +22 more
wiley +1 more source
Real‐World Comparison of Ticagrelor and Clopidogrel: Rosetta Stone or Lost in Translation?
Brian A. Bergmark
doaj +1 more source
Adamts1 Exacerbates Post‐Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8
Proposed mechanistic model of ADAMTS1‐ITGα8 mechanotransduction in post‐MI scar formation. Schematic illustration showing the mechanistic pathway by which endothelial cell (EC) derived Adamts1 regulates cardiac fibroblast activation through ITGα8‐mediated mechanotransduction following myocardial infarction (MI).
Chun‐Yan Kong +11 more
wiley +1 more source
PERIPHERAL GANGRENE IN MYOCARDIAL INFARCTION
W. G. A. Swan, C. B. Henderson
openalex +1 more source
The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He +9 more
wiley +1 more source
The Urinary Output of Catechol Derivatives Including Adrenaline in Normal Individuals, in Essential Hypertension, and in Myocardial Infarction [PDF]
Franklin R. Nuzum, Fritz Bischoff
openalex +1 more source
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li +8 more
wiley +1 more source

