Results 171 to 180 of about 1,287,660 (290)

Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m6A‐IGF2BP1 for Ischemic Stroke Rescue

Advanced Science, EarlyView.
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li, Yong‐Dong Guo, Xiao‐Wen Zhang, Zhi‐Yong Du, Yu‐Qi Wang, Zhuo Yang, Qian‐Wei Luo, Fang‐Fang Zhuo, Tian‐Tian Wei, Zheng‐Ping Liu, Bo Han, Wei Yu, Pei‐Pei Zhang, Wei Zhou, Zhi‐Yuan Lu, Peng‐Fei Tu, Chun‐Hong Zheng, Ke‐Wu Zeng   +17 more
wiley   +1 more source

Coinfection of SARS-CoV-2 and Influenza: A Catastrophic Coexistence. [PDF]

Infect Drug Resist
Jheng CY, Wang NC, Wang YC.
europepmc   +1 more source

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

Clinical and pathophysiological significance of circ-0049271 in acute ST-segment elevation myocardial infarction. [PDF]

J Int Med Res
Liao H, Xiao C, Li W, Xiang D.
europepmc   +1 more source

METTL3 drives heart failure by regulating Spp1 and Fos m6A modification in myocardial infarction [PDF]

Haixia Cheng, Le Li, Juying Qian, Yunzeng Zou, J Y, Junbo Ge   +5 more
openalex   +1 more source

Neuroprotective Nanoplatform Integrating Antioxidant MXene Nanozymes and Ferroptosis Inhibitors for Targeted Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Cerebral ischemia‐reperfusion injury (CIRI) is a key pathological process limiting the efficacy of stroke therapy. This study has developed an innovative, multifunctional, brain‐targeted nanoplatform (RFP) containing MXene nanoenzymes and ferroptosis inhibitors.
Lu Wang, Chao Hou, Shuo Li, Lizhi Yang, Yiqun Lin, Sen Wang, Xiaohua Jia, Hui Hui, Wen He, Wei Zhang   +9 more
wiley   +1 more source

Artery of Percheron Infarction Presenting With Profound Autonomic Dysfunction. [PDF]

Cureus
Abdul Halim S, Zakaria AZ, Bokti NA, Sapiai NA.   +3 more
europepmc   +1 more source

Worsening of Renal Function in Patients with STSegment Elevation Myocardial Infarction [PDF]

, 2018
Ailed Elena Rodriguez J
openalex   +1 more source

Os benefícios da atividade física na reabilitação cardíaca em pessoas pós-infarto agudo do miocárdio / The benefits of physical activity in cardiac rehabilitation in people post acute myocardial infarction

, 2022
Lucas Ortiz de Moraes Gomes, George Petrallás, Maria de Fátima Cataldi Paschoal, Lucas Agostini, Glaucia Betio Brunhara, Fernando Fabrizzi, Sabrina Ramires Sakamoto   +6 more
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source