Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics
Muralidharan and colleagues develop cell‐type‐specific transcriptomic aging clocks using single‐nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict age and identify distinct aging trajectories in specific brain cell types.
Chandramouli Muralidharan+12 more
wiley +1 more source
Bibliometric study and visualization of myocardial infarction combined with heart failure, 1993-2023. [PDF]
Wang K, Zhang S, Zhu M.
europepmc +1 more source
Shear‐activated nanoparticles carrying nitroglycerin selectively target high‐shear stress collateral vessels during ischaemic stroke, enhancing blood flow to at‐risk brain without systemic side effects. This novel approach significantly improves outcomes in animal models, outperforming conventional nitroglycerin delivery.
Magdalena Litman+21 more
wiley +1 more source
Glucose-Insulin-Potassium Therapy Guided by a Glucose-Controlled Insulin Infusion System in Acute Myocardinal Infarction [PDF]
Ball, P.+10 more
core +1 more source
Mitochondrial transplantation induces macrophage polarization toward an anti‐inflammatory M2 phenotype, enhances their reparative capacities, and facilitates mitochondrial transfer to cardiomyocytes, collectively promoting tissue repair and functional recovery post‐myocardial infarction.
Yuning Zhang+10 more
wiley +1 more source
Subacute left ventricular free wall rupture following acute myocardial infarction
Marc-Alexander Ohlow+2 more
doaj +1 more source
Correction: Prevalence of comorbidities associated with sickle cell disease among non-elderly individuals with commercial insurance-A retrospective cohort study. [PDF]
Ramsey SD+6 more
europepmc +1 more source
Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre‐mRNA
This work defines the context‐dependent function of Zc3h12c in macrophages using the Tnfrsf11a‐Cre system. It reveals Zc3h12c's dual mechanism—regulating RNA degradation and alternative splicing—with STAT1 as a key target. The findings elucidate a novel post‐transcriptional pathway and identify STAT1 isoforms as potential therapeutic targets for kidney
Chenyu Li+14 more
wiley +1 more source
Coronary Heart Disease: Angina Pectoris: Myocardial Infarction [PDF]
openalex +2 more sources
Implications of a new clinical classification of acute myocardial infarction. [PDF]
Thurston AJF+4 more
europepmc +1 more source