Results 61 to 70 of about 7,548,706 (340)

Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017.

Journal of the American Medical Association (JAMA), 2020
Importance Infection is frequent among patients in the intensive care unit (ICU). Contemporary information about the types of infections, causative pathogens, and outcomes can aid the development of policies for prevention, diagnosis, treatment, and ...
J. Vincent, Y. Sakr, M. Singer, I. Martín-Loeches, F. Machado, J. Marshall, S. Finfer, P. Pelosi, L. Brazzi, D. Aditianingsih, J. Timsit, B. Du, X. Wittebole, J. Máca, S. Kannan, L. Gorordo-Delsol, J. D. De Waele, Y. Mehta, M. Bonten, A. Khanna, M. Kollef, Marie Human, D. Angus   +22 more
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Comparison of antibody responses to SARS-CoV-2 variants in Australian children

Nature Communications, 2022
Despite a rise in COVID-19 cases among children, there is limited understanding of the antibody responses mounted, compared to in adults. In this work, authors compare seroconversion rates and antibody responses in unvaccinated Australian children across
Zheng Quan Toh, Nadia Mazarakis, Jill Nguyen, Rachel A. Higgins, Jeremy Anderson, Lien Anh Ha Do, David P. Burgner, Nigel Curtis, Andrew C. Steer, Kim Mulholland, Nigel W. Crawford, Shidan Tosif, Paul V. Licciardi   +12 more
doaj   +1 more source

Characteristics and anatomic location of PD-1 ⁺ TCF1 ⁺ stem-like CD8 T cells in chronic viral infection and cancer [PDF]

, 2023
Se Jin Im, Rebecca C. Obeng, Tahseen H. Nasti, Daniel T. McManus, Alice O. Kamphorst, Sivaram Gunisetty, Nataliya Prokhnevska, Jennifer W. Carlisle, Ke Yu, Gabriel Sica, Lucas Esteves Cardozo, André N. A. Gonçalves, Haydn Kissick, Helder I. Nakaya, Suresh S. Ramalingam, Rafi Ahmed   +15 more
openalex   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

Science, 2020
Immunity from reinfection One of the many open questions about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is whether an individual who has cleared the virus can be infected a second time and get sick. Chandrashekar et al.
A. Chandrashekar, Jinyan Liu, Amanda J. Martinot, K. McMahan, N. Mercado, Lauren Peter, Lisa H. Tostanoski, Jingyou Yu, Z. Maliga, M. Nekorchuk, K. Busman-Sahay, Margaret Terry, Linda M. Wrijil, Sarah Ducat, David R. Martinez, C. Atyeo, S. Fischinger, J. Burke, Matthew D. Slein, Laurent Pessaint, Alex Van Ry, J. Greenhouse, Tammy Taylor, Kelvin Blade, Anthony Cook, Brad Finneyfrock, Renita Brown, Elyse Teow, Jason Velasco, R. Zahn, F. Wegmann, P. Abbink, E. Bondzie, Gabriel Dagotto, M. Gebre, Xuan He, C. Jacob-Dolan, N. Kordana, Zhenfeng Li, M. Lifton, S. Mahrokhian, Lori F. Maxfield, Ramya Nityanandam, Joseph P. Nkolola, A. Schmidt, Andrew D. Miller, R. Baric, G. Alter, P. Sorger, J. Estes, H. Andersen, M. Lewis, D. Barouch   +52 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source