Results 171 to 180 of about 3,838,170 (313)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Nosocomial Infections in Trauma Patients Receiving Extracorporeal Membrane Oxygenation

The risk of infections in acute trauma patients receiving extracorporeal membrane oxygenation (ECMO) has not been well defined, but this population is among the sickest in the hospital.
Perkins, Oswald, Shagabayeva, Larisa, Collie, Brianna L, Lineen, Edward B, Laurendeau, Megan, Bustillos, Luciana Tito, Proctor, Kenneth G, Delamater, Jessica M, Cobler-Lichter, Michael D, Meizoso, Jonathan P, Lyons, Nicole B, Hart, Valerie, Machuca, Tiago, Namias, Nicholas, Parker, Brandon M   +14 more
core   +1 more source

Between Skin and Brain: A Systematic Review of 712 Cases 1976-2025 Reveals a Highly Diverse Disease Spectrum in Chaetothyriales. [PDF]

Mycoses
Li J, Wu H, Li Y, Li R, Smith DJ, de Hoog S, Song Y.   +6 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Effectiveness of leniolisib in reducing infections among patients with activated phosphoinositide 3-kinase δ syndrome (APDS). [PDF]

Immunol Res
Patel NC, Kuivinen J, MacKnight SD, Younger MEM, Germain G, Ripley S, Laliberté F, Fishman J, Harrington A.   +8 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Notes from the Field: Use of Enhanced Surveillance to Detect Severe Group A Streptococcus Infections Among Persons Experiencing Homelessness - Missoula County, Montana, July 2024-September 2025. [PDF]

MMWR Morb Mortal Wkly Rep
Hopkins B, Meehan AA, Mugel SG, Applegate BR, Black S, Silva JBB, Mutuc J, Edwards K, Jahnke J, Whitney P, Mozer M, Chochua S, Doll V, Baldry E, Lopeman J, Farr C, Gregory CJ, Williamson L, Mitchell CL.   +18 more
europepmc   +1 more source

Iron and Infection [PDF]

European Journal of Clinical Microbiology, 1985
openaire   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Ocular Injuries and Eye Safety Practices in Dental Settings: A Scoping Review. [PDF]

Int J Dent
Mascarenhas R, Rao S, Mala K, Rashmi SU, Mahajan P.   +4 more
europepmc   +1 more source