Results 121 to 130 of about 824,937 (282)

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source

ACUTE JOINT PAIN – A PAEDIATRIC INFECTIOUS DISEASES SPECIALIST’S PERSPECTIVE

Slovenska pediatrija
Pain in a joint can be a symptom of many illnesses. The most common infectious diseases are osteoarticular infections, typically affecting the lower extremities.
Katarina Slapšak, Katarina Vincek
doaj   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Treating Rheumatoid Arthritis yesterday and today [PDF]

, 2004
Rheumatoid arthritis is a chronic, systemic inflammatory disorder that mainly affects joints. It is the most common form of inflammatory joint disease, and the second commonest joint disease, osteoarthritis being the commonest.
Mallia, Carmel
core  

Therapeutic Effects of a Novel Tylophorine Analog, NK-007, on Collagen-Induced Arthritis Through Suppressing Tumor Necrosis Factor alpha Production and Th17 Cell Differentiation

, 2012
Objective. To analyze the effects of a novel compound, NK-007, on the prevention and treatment of collagen-induced arthritis (CIA) and the underlying mechanisms. Methods.
Hong, Zhangyong, Xiaolin Sun, Yuxiu Liu, Yuquan Lin, Yin, Zhinan, Zhanguo Li, Li, Yangguang, Wang, Puyue, Li, Zhanguo, Wu, Zhenzhou, Puyue Wang, Wang, Ziwen, Zhao, Liqing, Ti Wen, Meng Wu, Liqing Zhao, Lin, Yuquan, Wu, Meng, Wang, Qingmin, Bao, Xiucong, Zhangyong Hong, Xiucong Bao, Lin Han, Sun, Xiaolin, Guangchao Cao, Yangguang Li, Jianlei Hao, Han, Lin, Qingmin Wang, Liu, Yuxiu, Wen, Ti, Zhenzhou Wu, Zhinan Yin, Ziwen Wang, Hao, Jianlei, Cao, Guangchao   +35 more
core   +1 more source

Protease‐Triggered Chromogenic Release From Peptide‐Modified Calcium Carbonate Microspheres Enables Colorimetric Detection of Porphyromonas gingivalis Activity

Advanced Science, EarlyView.
We report a chromogenic release‐based assay system with protease‐cleavage peptide‐modified calcium carbonate microspheres for colorimetric detection of Porphyromonas (P.) gingivalis activity. In response to Arg‐specific gingipain secreted by P. gingivalis, the supernatant becomes colored, enabling colorimetric analysis and providing the monitoring of ...
Yuki Hiruta, Zhicheng Jin, Mari Adachi, Lubna Amer, Natalia O. Tjokro, Diego F. Trujillo, Jan Potempa, Anthony J. O'Donoghue, Casey Chen, Jesse V. Jokerst   +9 more
wiley   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Streptococcus dysgalactiae Septic Arthritis of a Pre-Weaned Holstein Bull Calf - a Case Report

Media Kedokteran Hewan
Septic arthritis is a joint inflammation caused by an infectious agent. Septic arthritis takes a long time to heal, and as such it may have a significant economic impact. A one-month-old Friesian Holstein calf was lame and had swelling in the left carpal
Vincent Setiawan, Raida Raisatulhaq, Septiyani   +2 more
doaj   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source