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Microglia, brain-resident innate immune cells, have been extensively studied in neurodegenerative contexts like Alzheimer's disease. The Coronavirus disease 2019 (COVID-19) pandemic highlighted how peripheral infection and inflammation can be detrimental to the neuroimmune milieu and initiate microgliosis driven by peripheral inflammation.
Herman, Li +2 more
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Herman, Li +2 more
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Immunosenescence and infectious diseases
Microbes and Infection, 2001Infectious diseases are major causes, with malignancies, of morbidity and mortality in the elderly. Increased susceptibility to infections may result from underlying dysfunction of an aged immune system; moreover, inappropriate immunologic functions associated with aging can determine an insufficient response to vaccines.
GINALDI, Lia +4 more
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The Mathematics of Infectious Diseases
SIAM Review, 2000Summary: Many models for the spread of infectious diseases in populations have been analyzed mathematically and applied to specific diseases. Threshold theorems involving the basic reproduction number \(R_{0}\), the contact number \(\sigma\), and the replacement number \(R\) are reviewed for the classic SIR epidemic and endemic models.
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Infectious disease in an era of global change
Nature Reviews Microbiology, 2021Caroline Wagner +2 more
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The Human “Contaminome” and Understanding Infectious Disease
New England Journal of Medicine, 2022Steven L Salzberg
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Risks of Infectious Disease in Xenotransplantation
New England Journal of Medicine, 2022Jay Fishman
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Advances in Artificial Intelligence for Infectious-Disease Surveillance
New England Journal of Medicine, 2023John Brownstein +2 more
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