Results 31 to 40 of about 1,423,325 (211)
Nihon Naika Gakkai Zasshi, 1997 レジオネラは土壌細菌で世界中に分布しているが,近代の文化的生活における人工環境の至る所で増殖し,近年新たな展開を見せている.特に,人工環境水においては共存するアメーバを媒体として大量に増殖し,ありとあらゆる環境水からレジオネラ感染の危険性が高まっている.人工環境水の消毒の問題は人体への影響を考慮する必要があり,困難をきわめている状態である.わが国にはビル管理基準としての冷却塔におけるレジオネラ症防止指針が作成されているが,米国のCDCのような院内感染防止指針やその他の環境水に対する水の管理基準の策定はこれからである.診断法はPCR法や尿中抗原検出などかなりの進歩が見られているので,疑わしい症例では積極的にしかるべき施設へ依頼してでも確定診断を得る努力をする必要がある.
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Nihon Naika Gakkai Zasshi, 1997 ハンタウイルスとは,ブニヤウイルス科ハンタウイルス属に含まれる一群のウイルスを指す総称である.その名は1973年李たちによって分離されたハンターンウイルスに由来する.ヒトに腎症候性出血熱(HFRS)やハンタウイルス肺症候群(HPS)など劇症の感染症をおこすウイルスが含まれる.ハンタウイルスの自然宿主は齧歯類であり,感染個体由来の乾燥した排泄物のエアゾールを介してヒトにも感染する.
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
, 2018 In this chapter, we consider whether individual differences might play role in how a behavioral immune system operates and what that implies for human personality. We first highlight the theoretical reasons to expect variation in pathogen management mechanisms and the psychological models relevant to these mechanisms (e.g., behavioral immune system ...
Ackerman , Joshua +2 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source